2idy

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[[Image:2idy.gif|left|200px]]
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{{STRUCTURE_2idy| PDB=2idy | SCENE= }}
{{STRUCTURE_2idy| PDB=2idy | SCENE= }}
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'''NMR Structure of the SARS-CoV non-structural protein nsp3a'''
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===NMR Structure of the SARS-CoV non-structural protein nsp3a===
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==Overview==
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This paper describes the structure determination of nsp3a, the N-terminal domain of the severe acute respiratory syndrome coronavirus (SARS-CoV) nonstructural protein 3. nsp3a exhibits a ubiquitin-like globular fold of residues 1 to 112 and a flexibly extended glutamic acid-rich domain of residues 113 to 183. In addition to the four beta-strands and two alpha-helices that are common to ubiquitin-like folds, the globular domain of nsp3a contains two short helices representing a feature that has not previously been observed in these proteins. Nuclear magnetic resonance chemical shift perturbations showed that these unique structural elements are involved in interactions with single-stranded RNA. Structural similarities with proteins involved in various cell-signaling pathways indicate possible roles of nsp3a in viral infection and persistence.
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(as it appears on PubMed at http://www.pubmed.gov), where 17728234 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17728234}}
==About this Structure==
==About this Structure==
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2IDY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IDY OCA].
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2IDY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IDY OCA].
==Reference==
==Reference==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Viral protein]]
[[Category: Viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:23:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:16:33 2008''

Revision as of 09:16, 28 July 2008

Image:2idy.png

Template:STRUCTURE 2idy

NMR Structure of the SARS-CoV non-structural protein nsp3a

Template:ABSTRACT PUBMED 17728234

About this Structure

2IDY is a Single protein structure of sequence from Sars coronavirus. Full experimental information is available from OCA.

Reference

Nuclear magnetic resonance structure of the N-terminal domain of nonstructural protein 3 from the severe acute respiratory syndrome coronavirus., Serrano P, Johnson MA, Almeida MS, Horst R, Herrmann T, Joseph JS, Neuman BW, Subramanian V, Saikatendu KS, Buchmeier MJ, Stevens RC, Kuhn P, Wuthrich K, J Virol. 2007 Nov;81(21):12049-60. Epub 2007 Aug 29. PMID:17728234

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