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2seb

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[[Image:2seb.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_2seb| PDB=2seb | SCENE= }}
{{STRUCTURE_2seb| PDB=2seb | SCENE= }}
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'''X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH A PEPTIDE FROM HUMAN COLLAGEN II'''
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===X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH A PEPTIDE FROM HUMAN COLLAGEN II===
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==Overview==
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Genetic predisposition to rheumatoid arthritis (RA) is linked to the MHC class II allele HLA-DR4. The charge of the amino acid at DRbeta71 in the peptide-binding site appears to be critical in discriminating DR molecules linked to increased disease susceptibility. We have determined the 2.5 A x-ray structure of the DR4 molecule with the strongest linkage to RA (DRB1*0401) complexed with a human collagen II peptide. Details of a predicted salt bridge between lysine DRbeta71 and aspartic acid at the P4 peptide position suggest how it may participate in both antigen binding and TCR activation. A model is proposed for the DR4 recognition of collagen II (261-273), an antigen immunodominant in human-transgenic mouse models of RA.
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The line below this paragraph, {{ABSTRACT_PUBMED_9354468}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9354468 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9354468}}
==About this Structure==
==About this Structure==
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[[Category: Wiley, D C.]]
[[Category: Wiley, D C.]]
[[Category: Zaller, D M.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:17:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:19:10 2008''

Revision as of 09:19, 28 July 2008

Image:2seb.png

Template:STRUCTURE 2seb

X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH A PEPTIDE FROM HUMAN COLLAGEN II

Template:ABSTRACT PUBMED 9354468

About this Structure

2SEB is a Protein complex structure of sequences from Homo sapiens and Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II., Dessen A, Lawrence CM, Cupo S, Zaller DM, Wiley DC, Immunity. 1997 Oct;7(4):473-81. PMID:9354468

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