2c7z

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2c7z.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2c7z.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2c7z| PDB=2c7z | SCENE= }}
{{STRUCTURE_2c7z| PDB=2c7z | SCENE= }}
-
'''PLANT ENZYME CRYSTAL FORM II'''
+
===PLANT ENZYME CRYSTAL FORM II===
-
==Overview==
+
<!--
-
Crystal structures of peroxisomal Arabidopsis thaliana 3-ketoacyl-CoA thiolase (AtKAT), an enzyme of fatty acid beta-oxidation, are reported. The subunit, a typical thiolase, is a combination of two similar alpha/beta domains capped with a loop domain. The comparison of AtKAT with the Saccharomyces cerevisiae homologue (ScKAT) structure reveals a different placement of subunits within the functional dimers and that a polypeptide segment forming an extended loop around the open catalytic pocket of ScKAT converts to alpha-helix in AtKAT, and occludes the active site. A disulfide is formed between Cys192, on this helix, and Cys138, a catalytic residue. Access to Cys138 is determined by the structure of this polypeptide segment. AtKAT represents an oxidized, previously unknown inactive form, whilst ScKAT is the reduced and active enzyme. A high level of sequence conservation is observed, including Cys192, in eukaryotic peroxisomal, but not mitochondrial or prokaryotic KAT sequences, for this labile loop/helix segment. This indicates that KAT activity in peroxisomes is influenced by a disulfide/dithiol change linking fatty acid beta-oxidation with redox regulation.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16630629}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16630629 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16630629}}
==About this Structure==
==About this Structure==
Line 34: Line 38:
[[Category: Oxylipin synthesis]]
[[Category: Oxylipin synthesis]]
[[Category: Transferase]]
[[Category: Transferase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:25:01 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:21:38 2008''

Revision as of 09:21, 28 July 2008

Image:2c7z.png

Template:STRUCTURE 2c7z

PLANT ENZYME CRYSTAL FORM II

Template:ABSTRACT PUBMED 16630629

About this Structure

2C7Z is a Single protein structure of sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.

Reference

The crystal structure of a plant 3-ketoacyl-CoA thiolase reveals the potential for redox control of peroxisomal fatty acid beta-oxidation., Sundaramoorthy R, Micossi E, Alphey MS, Germain V, Bryce JH, Smith SM, Leonard GA, Hunter WN, J Mol Biol. 2006 Jun 2;359(2):347-57. Epub 2006 Mar 29. PMID:16630629

Page seeded by OCA on Mon Jul 28 12:21:38 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2c7z"
Personal tools