2o8a

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{{Seed}}
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{{STRUCTURE_2o8a| PDB=2o8a | SCENE= }}
{{STRUCTURE_2o8a| PDB=2o8a | SCENE= }}
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'''rat PP1cgamma complexed with mouse inhibitor-2'''
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===rat PP1cgamma complexed with mouse inhibitor-2===
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==Overview==
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The functional specificity of type 1 protein phosphatases (PP1) depends on the associated regulatory/targeting and inhibitory subunits. To gain insights into the mechanism of PP1 regulation by inhibitor-2, an ancient and intrinsically disordered regulator, we solved the crystal structure of the complex to 2.5A resolution. Our studies show that, when complexed with PP1c, I-2 acquires three regions of order: site 1, residues 12-17, binds adjacent to a region recognized by many PP1 regulators; site 2, amino acids 44-56, interacts along the RVXF binding groove through an unsuspected sequence, KSQKW; and site 3, residues 130-169, forms alpha-helical regions that lie across the substrate-binding cleft. Specifically, residues 148-151 interact at the catalytic center, displacing essential metal ions, accounting for both rapid inhibition and slower inactivation of PP1c. Thus, our structure provides novel insights into the mechanism of PP1 inhibition and subsequent reactivation, has broad implications for the physiological regulation of PP1, and highlights common inhibitory interactions among phosphoprotein phosphatase family members.
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{{ABSTRACT_PUBMED_17636256}}
==About this Structure==
==About this Structure==
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[[Category: Inhibitor-2]]
[[Category: Inhibitor-2]]
[[Category: Protein phosphatase]]
[[Category: Protein phosphatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:26:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:28:06 2008''

Revision as of 09:28, 28 July 2008

Image:2o8a.png

Template:STRUCTURE 2o8a

rat PP1cgamma complexed with mouse inhibitor-2

Template:ABSTRACT PUBMED 17636256

About this Structure

2O8A is a Protein complex structure of sequences from Mus musculus and Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structural basis for regulation of protein phosphatase 1 by inhibitor-2., Hurley TD, Yang J, Zhang L, Goodwin KD, Zou Q, Cortese M, Dunker AK, DePaoli-Roach AA, J Biol Chem. 2007 Sep 28;282(39):28874-83. Epub 2007 Jul 18. PMID:17636256

Page seeded by OCA on Mon Jul 28 12:28:06 2008

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