1zfd

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{{STRUCTURE_1zfd| PDB=1zfd | SCENE= }}
{{STRUCTURE_1zfd| PDB=1zfd | SCENE= }}
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'''SWI5 ZINC FINGER DOMAIN 2, NMR, 45 STRUCTURES'''
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===SWI5 ZINC FINGER DOMAIN 2, NMR, 45 STRUCTURES===
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==Overview==
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This paper describes the detailed three-dimensional structures of two zinc-finger domains from the yeast transcription factor SWI5, calculated using the results of the n.m.r. experiments described in the accompanying paper. The structure of finger 2 is essentially similar to those previously obtained by others for isolated, synthetic single zinc-finger domains in solution, and for the three zinc-finger peptide Zif268 in its crystalline complex with DNA. The N-terminal half of the sequence forms a two-stranded, irregular beta-sheet containing both of the metal-binding cysteine residues, while the remainder of the structure forms a helix. Approximately the first half of this helix is alpha-helical, whereas the C-terminal portion, including the two metal-binding histidine residues, is 3(10) helical. Four invariant hydrophobic residues form a core to the structure. In contrast to all previously described structures of zinc-finger domains, finger 1 has an additional strand in the beta-sheet, formed by residues N-terminal to the formal start of the finger motif. This additional strand plays a role in stabilising the folded form of finger 1, since a two-finger peptide lacking the N-terminal residues showed folded structure in finger 2 but not in finger 1.
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(as it appears on PubMed at http://www.pubmed.gov), where 1453468 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1453468}}
==About this Structure==
==About this Structure==
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1ZFD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFD OCA].
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1ZFD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZFD OCA].
==Reference==
==Reference==
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[[Category: Dna binding motif]]
[[Category: Dna binding motif]]
[[Category: Zinc finger dna binding domain]]
[[Category: Zinc finger dna binding domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:33:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:29:15 2008''

Revision as of 09:29, 28 July 2008

Image:1zfd.png

Template:STRUCTURE 1zfd

SWI5 ZINC FINGER DOMAIN 2, NMR, 45 STRUCTURES

Template:ABSTRACT PUBMED 1453468

About this Structure

1ZFD is a Single protein structure of sequence from Saccharomyces cerevisiae. Full experimental information is available from OCA.

Reference

Solution structures of two zinc-finger domains from SWI5 obtained using two-dimensional 1H nuclear magnetic resonance spectroscopy. A zinc-finger structure with a third strand of beta-sheet., Neuhaus D, Nakaseko Y, Schwabe JW, Klug A, J Mol Biol. 1992 Nov 20;228(2):637-51. PMID:1453468

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