1umu

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{{STRUCTURE_1umu| PDB=1umu | SCENE= }}
{{STRUCTURE_1umu| PDB=1umu | SCENE= }}
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'''STRUCTURE DETERMINATION OF UMUD' BY MAD PHASING OF THE SELENOMETHIONYL PROTEIN'''
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===STRUCTURE DETERMINATION OF UMUD' BY MAD PHASING OF THE SELENOMETHIONYL PROTEIN===
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==Overview==
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For life to be sustained, mistakes in DNA repair must be tolerated when damage obscures the genetic information. In bacteria such as Escherichia coli, DNA damage elicits the well regulated 'SOS response'. For the extreme case of damage that cannot be repaired by conventional enzymes, there are proteins that allow the replication of DNA through such lesions, but with a reduction in the fidelity of replication. Essential proteins in this mutagenic process are RecA, DNA polymerase III, UmuD, UmuD' and UmuC (umu: UV mutagenesis). Regulation of this response involves a RecA-mediated self-cleavage of UmuD to produce UmuD'. To understand this system in more detail, we have determined the crystal structure of the E. coli UmuD' mutagenesis protein at 2.5 A resolution. Globular heads folded in an unusual Beta-structure associate to form molecular dimers, and extended amino-terminal tails associate to produce crystallized filaments. The structure provides insight into the mechanism of the self-cleavage reaction that UmuD-like proteins undergo as part of the global SOS response.
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{{ABSTRACT_PUBMED_8614470}}
==About this Structure==
==About this Structure==
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[[Category: Lexa repressor]]
[[Category: Lexa repressor]]
[[Category: Sos mutagenesis]]
[[Category: Sos mutagenesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:26:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:30:54 2008''

Revision as of 09:31, 28 July 2008

Image:1umu.png

Template:STRUCTURE 1umu

STRUCTURE DETERMINATION OF UMUD' BY MAD PHASING OF THE SELENOMETHIONYL PROTEIN

Template:ABSTRACT PUBMED 8614470

About this Structure

1UMU is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of the UmuD' protein and its regulation in response to DNA damage., Peat TS, Frank EG, McDonald JP, Levine AS, Woodgate R, Hendrickson WA, Nature. 1996 Apr 25;380(6576):727-30. PMID:8614470

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