1pyn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1pyn.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1pyn.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1pyn| PDB=1pyn | SCENE= }}
{{STRUCTURE_1pyn| PDB=1pyn | SCENE= }}
-
'''DUAL-SITE POTENT, SELECTIVE PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR USING A LINKED FRAGMENT STRATEGY AND A MALONATE HEAD ON THE FIRST SITE'''
+
===DUAL-SITE POTENT, SELECTIVE PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR USING A LINKED FRAGMENT STRATEGY AND A MALONATE HEAD ON THE FIRST SITE===
-
==Overview==
+
<!--
-
A salicylate second site binder was linked to three classes of phosphotyrosine mimetics to produce potent protein tyrosine phosphatase 1B (PTP1B) inhibitors which exhibit significant selectivity against other phosphatases including the most homologous member, TCPTP.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12951078}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12951078 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12951078}}
==About this Structure==
==About this Structure==
Line 35: Line 39:
[[Category: Malonate-containing inhibitor]]
[[Category: Malonate-containing inhibitor]]
[[Category: Protein tyrosine phosphatase inhibited with dual site]]
[[Category: Protein tyrosine phosphatase inhibited with dual site]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:39:01 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:34:10 2008''

Revision as of 09:34, 28 July 2008

Image:1pyn.png

Template:STRUCTURE 1pyn

DUAL-SITE POTENT, SELECTIVE PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR USING A LINKED FRAGMENT STRATEGY AND A MALONATE HEAD ON THE FIRST SITE

Template:ABSTRACT PUBMED 12951078

About this Structure

1PYN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors., Pei Z, Li X, Liu G, Abad-Zapatero C, Lubben T, Zhang T, Ballaron SJ, Hutchins CW, Trevillyan JM, Jirousek MR, Bioorg Med Chem Lett. 2003 Oct 6;13(19):3129-32. PMID:12951078

Page seeded by OCA on Mon Jul 28 12:34:10 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1pyn"
Personal tools