2nwm

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[[Image:2nwm.gif|left|200px]]
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{{STRUCTURE_2nwm| PDB=2nwm | SCENE= }}
{{STRUCTURE_2nwm| PDB=2nwm | SCENE= }}
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'''Solution structure of the first SH3 domain of human Vinexin and its interaction with the peptides from Vinculin'''
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===Solution structure of the first SH3 domain of human Vinexin and its interaction with the peptides from Vinculin===
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==Overview==
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Solution structure of the first Src homology (SH) 3 domain of human vinexin (V_SH3_1) was determined using nuclear magnetic resonance (NMR) method and revealed that it was a canonical SH3 domain, which has a typical beta-beta-beta-beta-alpha-beta fold. Using chemical shift perturbation and surface plasmon resonance experiments, we studied the binding properties of the SH3 domain with two different peptides from vinculin hinge regions: P856 and P868. The observations illustrated slightly different affinities of the two peptides binding to V_SH3_1. The interaction between P868 and V_SH3_1 belonged to intermediate exchange with a modest binding affinity, while the interaction between P856 and V_SH3_1 had a low binding affinity. The structure and ligand-binding interface of V_SH3_1 provide a structural basis for the further functional study of this important molecule.
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(as it appears on PubMed at http://www.pubmed.gov), where 17467669 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17467669}}
==About this Structure==
==About this Structure==
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2NWM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NWM OCA].
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2NWM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NWM OCA].
==Reference==
==Reference==
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[[Category: Zhang, J.]]
[[Category: Zhang, J.]]
[[Category: Vinexin sh3 domain]]
[[Category: Vinexin sh3 domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:00:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:34:38 2008''

Revision as of 09:34, 28 July 2008

Image:2nwm.png

Template:STRUCTURE 2nwm

Solution structure of the first SH3 domain of human Vinexin and its interaction with the peptides from Vinculin

Template:ABSTRACT PUBMED 17467669

About this Structure

2NWM is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the first SH3 domain of human vinexin and its interaction with vinculin peptides., Zhang J, Li X, Yao B, Shen W, Sun H, Xu C, Wu J, Shi Y, Biochem Biophys Res Commun. 2007 Jun 15;357(4):931-7. Epub 2007 Apr 17. PMID:17467669

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