1qou

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[[Image:1qou.gif|left|200px]]
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{{STRUCTURE_1qou| PDB=1qou | SCENE= }}
{{STRUCTURE_1qou| PDB=1qou | SCENE= }}
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'''CEN (CENTRORADIALIS) PROTEIN FROM ANTIRRHINUM'''
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===CEN (CENTRORADIALIS) PROTEIN FROM ANTIRRHINUM===
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==Overview==
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Expression of the plant protein centroradialis (CEN) leads to a morphological switch between shoot growth and the development of flower structures (inflorescence). We have determined the crystal structure of Antirrhinum CEN to 1.9 A resolution. This structure confirms the CEN proteins as a subset of the family of phosphatidylethanolamine-binding proteins (PEBP), as predicted from sequence homology. Mammalian forms of PEBP have been found to act as inhibitors of MAP kinase signalling, a central signalling cascade regulating cell differentiation. CEN and PEBP proteins share a similar topology dominated by a large central beta-sheet. The strong conservation of a binding pocket at one end of this sheet which is capable of binding phosphoryl ligands, suggests the biological effects of CEN, like PEBP, arise from the ability of this region to form complexes with phosphorylated ligands, hence interfering with kinases and their effectors.
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(as it appears on PubMed at http://www.pubmed.gov), where 10764580 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10764580}}
==About this Structure==
==About this Structure==
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[[Category: Member of the phosphatidylethanolamine binding protein family]]
[[Category: Member of the phosphatidylethanolamine binding protein family]]
[[Category: Signalling]]
[[Category: Signalling]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:31:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:36:46 2008''

Revision as of 09:36, 28 July 2008

Image:1qou.png

Template:STRUCTURE 1qou

CEN (CENTRORADIALIS) PROTEIN FROM ANTIRRHINUM

Template:ABSTRACT PUBMED 10764580

About this Structure

1QOU is a Single protein structure of sequence from Antirrhinum majus. Full crystallographic information is available from OCA.

Reference

The structure of Antirrhinum centroradialis protein (CEN) suggests a role as a kinase regulator., Banfield MJ, Brady RL, J Mol Biol. 2000 Apr 14;297(5):1159-70. PMID:10764580

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