2giu

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[[Image:2giu.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2giu| PDB=2giu | SCENE= }}
{{STRUCTURE_2giu| PDB=2giu | SCENE= }}
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'''Human estrogen receptor beta ligand-binding domain in complex with compound 45'''
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===Human estrogen receptor beta ligand-binding domain in complex with compound 45===
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==Overview==
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Synthesis and derivatization of a series of substituted tetrahydrofluorenone analogs giving potent, ERbeta subtype selective ligands are described. Several analogs possessing ERbeta binding affinities comparable to 17beta-estradiol but with greater than 75-fold selectivity over ERalpha are reported.
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The line below this paragraph, {{ABSTRACT_PUBMED_16632357}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16632357 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16632357}}
==About this Structure==
==About this Structure==
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[[Category: Nuclear receptor]]
[[Category: Nuclear receptor]]
[[Category: Transcription factor]]
[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:09:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:37:13 2008''

Revision as of 09:37, 28 July 2008

Template:STRUCTURE 2giu

Human estrogen receptor beta ligand-binding domain in complex with compound 45

Template:ABSTRACT PUBMED 16632357

About this Structure

2GIU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The discovery of tetrahydrofluorenones as a new class of estrogen receptor beta-subtype selective ligands., Wilkening RR, Ratcliffe RW, Tynebor EC, Wildonger KJ, Fried AK, Hammond ML, Mosley RT, Fitzgerald PM, Sharma N, McKeever BM, Nilsson S, Carlquist M, Thorsell A, Locco L, Katz R, Frisch K, Birzin ET, Wilkinson HA, Mitra S, Cai S, Hayes EC, Schaeffer JM, Rohrer SP, Bioorg Med Chem Lett. 2006 Jul 1;16(13):3489-94. Epub 2006 May 2. PMID:16632357

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