1uao

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[[Image:1uao.gif|left|200px]]
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{{Seed}}
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[[Image:1uao.png|left|200px]]
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{{STRUCTURE_1uao| PDB=1uao | SCENE= }}
{{STRUCTURE_1uao| PDB=1uao | SCENE= }}
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'''NMR Structure of designed protein, Chignolin, consisting of only ten amino acids (Ensembles)'''
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===NMR Structure of designed protein, Chignolin, consisting of only ten amino acids (Ensembles)===
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==Overview==
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We have designed a peptide termed chignolin, consisting of only 10 amino acid residues (GYDPETGTWG), on the basis of statistics derived from more than 10,000 protein segments. The peptide folds into a unique structure in water and shows a cooperative thermal transition, both of which may be hallmarks of a protein. Also, the experimentally determined beta-hairpin structure was very close to what we had targeted. The performance of the short peptide not only implies that the methodology employed here can contribute toward development of novel techniques for protein design, but it also yields insights into the raison d'etre of an autonomous element involved in a natural protein. This is of interest for the pursuit of folding mechanisms and evolutionary processes of proteins.
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The line below this paragraph, {{ABSTRACT_PUBMED_15296744}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15296744 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15296744}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAO OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAO OCA].
==Reference==
==Reference==
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[[Category: G-peptide]]
[[Category: G-peptide]]
[[Category: Mini-protein]]
[[Category: Mini-protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:58:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:44:51 2008''

Revision as of 09:44, 28 July 2008

Image:1uao.png

Template:STRUCTURE 1uao

NMR Structure of designed protein, Chignolin, consisting of only ten amino acids (Ensembles)

Template:ABSTRACT PUBMED 15296744

About this Structure

Full experimental information is available from OCA.

Reference

10 residue folded peptide designed by segment statistics., Honda S, Yamasaki K, Sawada Y, Morii H, Structure. 2004 Aug;12(8):1507-18. PMID:15296744

Page seeded by OCA on Mon Jul 28 12:44:51 2008

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