1z8s

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[[Image:1z8s.gif|left|200px]]
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[[Image:1z8s.png|left|200px]]
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{{STRUCTURE_1z8s| PDB=1z8s | SCENE= }}
{{STRUCTURE_1z8s| PDB=1z8s | SCENE= }}
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'''DnaB binding domain of DnaG (P16) from Bacillus stearothermophilus (residues 452-597)'''
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===DnaB binding domain of DnaG (P16) from Bacillus stearothermophilus (residues 452-597)===
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==Overview==
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The helicase-primase interaction is a critical event in DNA replication and is mediated by a putative helicase-interaction domain within the primase. The solution structure of the helicase-interaction domain of DnaG reveals that it is made up of two independent subdomains: an N-terminal six-helix module and a C-terminal two-helix module that contains the residues of the primase previously identified as important in the interaction with the helicase. We show that the two-helix module alone is sufficient for strong binding between the primase and the helicase but fails to activate the helicase; both subdomains are required for helicase activation. The six-helix module of the primase has only one close structural homolog, the N-terminal domain of the corresponding helicase. This surprising structural relationship, coupled with the differences in surface properties of the two molecules, suggests how the helicase-interaction domain may perturb the structure of the helicase and lead to activation.
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The line below this paragraph, {{ABSTRACT_PUBMED_15837199}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15837199 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15837199}}
==About this Structure==
==About this Structure==
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1Z8S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z8S OCA].
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1Z8S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z8S OCA].
==Reference==
==Reference==
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[[Category: Waltho, J P.]]
[[Category: Waltho, J P.]]
[[Category: Two alpha helical sub-domain]]
[[Category: Two alpha helical sub-domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:19:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:50:02 2008''

Revision as of 09:50, 28 July 2008

Image:1z8s.png

Template:STRUCTURE 1z8s

DnaB binding domain of DnaG (P16) from Bacillus stearothermophilus (residues 452-597)

Template:ABSTRACT PUBMED 15837199

About this Structure

1Z8S is a Single protein structure of sequence from Geobacillus stearothermophilus. Full experimental information is available from OCA.

Reference

Solution structure of the helicase-interaction domain of the primase DnaG: a model for helicase activation., Syson K, Thirlway J, Hounslow AM, Soultanas P, Waltho JP, Structure. 2005 Apr;13(4):609-16. PMID:15837199

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