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1rc7

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{{STRUCTURE_1rc7| PDB=1rc7 | SCENE= }}
{{STRUCTURE_1rc7| PDB=1rc7 | SCENE= }}
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'''Crystal structure of RNase III Mutant E110K from Aquifex Aeolicus complexed with ds-RNA at 2.15 Angstrom Resolution'''
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===Crystal structure of RNase III Mutant E110K from Aquifex Aeolicus complexed with ds-RNA at 2.15 Angstrom Resolution===
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==Overview==
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Ribonuclease III (RNase III) represents a family of double-stranded RNA (dsRNA) endonucleases. The simplest bacterial enzyme contains an endonuclease domain (endoND) and a dsRNA binding domain (dsRBD). RNase III can affect RNA structure and gene expression in either of two ways: as a dsRNA-processing enzyme that cleaves dsRNA, or as a dsRNA binding protein that binds but does not cleave dsRNA. We previously determined the endoND structure of Aquifex aeolicus RNase III (Aa-RNase III) and modeled a catalytic complex of full-length Aa-RNase III with dsRNA. Here, we present the crystal structure of Aa-RNase III in complex with dsRNA, revealing a noncatalytic assembly. The major differences between the two functional forms of RNase III.dsRNA are the conformation of the protein and the orientation and location of dsRNA. The flexibility of a 7 residue linker between the endoND and dsRBD enables the transition between these two forms.
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(as it appears on PubMed at http://www.pubmed.gov), where 15016361 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15016361}}
==About this Structure==
==About this Structure==
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[[Category: Ribonuclease iii]]
[[Category: Ribonuclease iii]]
[[Category: Rna interference]]
[[Category: Rna interference]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:19:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:50:44 2008''

Revision as of 09:50, 28 July 2008

Image:1rc7.png

Template:STRUCTURE 1rc7

Crystal structure of RNase III Mutant E110K from Aquifex Aeolicus complexed with ds-RNA at 2.15 Angstrom Resolution

Template:ABSTRACT PUBMED 15016361

About this Structure

1RC7 is a Single protein structure of sequence from Aquifex aeolicus. Full crystallographic information is available from OCA.

Reference

Noncatalytic assembly of ribonuclease III with double-stranded RNA., Blaszczyk J, Gan J, Tropea JE, Court DL, Waugh DS, Ji X, Structure. 2004 Mar;12(3):457-66. PMID:15016361

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