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1wqj

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{{STRUCTURE_1wqj| PDB=1wqj | SCENE= }}
{{STRUCTURE_1wqj| PDB=1wqj | SCENE= }}
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'''Structural Basis for the Regulation of Insulin-Like Growth Factors (IGFs) by IGF Binding Proteins (IGFBPs)'''
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===Structural Basis for the Regulation of Insulin-Like Growth Factors (IGFs) by IGF Binding Proteins (IGFBPs)===
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==Overview==
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Insulin-like growth factor binding proteins (IGFBPs) control the extracellular distribution, function, and activity of IGFs. Here, we report an X-ray structure of the binary complex of IGF-I and the N-terminal domain of IGFBP-4 (NBP-4, residues 3-82) and a model of the ternary complex of IGF-I, NBP-4, and the C-terminal domain (CBP-4, residues 151-232) derived from diffraction data with weak definition of the C-terminal domain. These structures show how the IGFBPs regulate IGF signaling. Key features of the structures include (1) a disulphide bond ladder that binds to IGF and partially masks the IGF residues responsible for type 1 IGF receptor (IGF-IR) binding, (2) the high-affinity IGF-I interaction site formed by residues 39-82 in a globular fold, and (3) CBP-4 interactions. Although CBP-4 does not bind individually to either IGF-I or NBP-4, in the ternary complex, CBP-4 contacts both and also blocks the IGF-IR binding region of IGF-I.
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The line below this paragraph, {{ABSTRACT_PUBMED_15642270}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15642270 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15642270}}
==About this Structure==
==About this Structure==
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[[Category: Disulfide rich]]
[[Category: Disulfide rich]]
[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:00:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:53:43 2008''

Revision as of 09:53, 28 July 2008

Image:1wqj.png

Template:STRUCTURE 1wqj

Structural Basis for the Regulation of Insulin-Like Growth Factors (IGFs) by IGF Binding Proteins (IGFBPs)

Template:ABSTRACT PUBMED 15642270

About this Structure

1WQJ is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for the regulation of insulin-like growth factors by IGF binding proteins., Siwanowicz I, Popowicz GM, Wisniewska M, Huber R, Kuenkele KP, Lang K, Engh RA, Holak TA, Structure. 2005 Jan;13(1):155-67. PMID:15642270

Page seeded by OCA on Mon Jul 28 12:53:43 2008

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