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1mxp

From Proteopedia

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[[Image:1mxp.gif|left|200px]]
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{{STRUCTURE_1mxp| PDB=1mxp | SCENE= }}
{{STRUCTURE_1mxp| PDB=1mxp | SCENE= }}
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'''Solution structure of the ribbon disulfide bond isomer of alpha-conotoxin AuIB'''
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===Solution structure of the ribbon disulfide bond isomer of alpha-conotoxin AuIB===
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==Overview==
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alpha-Conotoxin AuIB and a disulfide bond variant of AuIB have been synthesized to determine the role of disulfide bond connectivity on structure and activity. Both of these peptides contain the 15 amino acid sequence GCCSYPPCFATNPDC, with the globular (native) isomer having the disulfide connectivity Cys(2-8 and 3-15) and the ribbon isomer having the disulfide connectivity Cys(2-15 and 3-8). The solution structures of the peptides were determined by NMR spectroscopy, and their ability to block the nicotinic acetylcholine receptors on dissociated neurons of the rat parasympathetic ganglia was examined. The ribbon disulfide isomer, although having a less well defined structure, is surprisingly found to have approximately 10 times greater potency than the native peptide. To our knowledge this is the first demonstration of a non-native disulfide bond isomer of a conotoxin exhibiting greater biological activity than the native isomer.
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The line below this paragraph, {{ABSTRACT_PUBMED_12376538}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12376538 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12376538}}
==About this Structure==
==About this Structure==
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1MXP is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MXP OCA].
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1MXP is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MXP OCA].
==Reference==
==Reference==
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[[Category: Hogg, R C.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:50:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:06:56 2008''

Revision as of 10:07, 28 July 2008

Image:1mxp.png

Template:STRUCTURE 1mxp

Solution structure of the ribbon disulfide bond isomer of alpha-conotoxin AuIB

Template:ABSTRACT PUBMED 12376538

About this Structure

1MXP is a Single protein structure. Full experimental information is available from OCA.

Reference

A new level of conotoxin diversity, a non-native disulfide bond connectivity in alpha-conotoxin AuIB reduces structural definition but increases biological activity., Dutton JL, Bansal PS, Hogg RC, Adams DJ, Alewood PF, Craik DJ, J Biol Chem. 2002 Dec 13;277(50):48849-57. Epub 2002 Oct 9. PMID:12376538

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