1tq6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1tq6.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1tq6.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1tq6| PDB=1tq6 | SCENE= }}
{{STRUCTURE_1tq6| PDB=1tq6 | SCENE= }}
-
'''Crystal Structure of IIGP1: a paradigm for interferon inducible p47 resistance GTPases'''
+
===Crystal Structure of IIGP1: a paradigm for interferon inducible p47 resistance GTPases===
-
==Overview==
+
<!--
-
Interferon-inducible p47 GTPases are critical mediators of cell-autonomous resistance against several intracellular pathogens. Here we present the first crystal structure of a member of this novel GTPase family, IIGP1, in its nucleotide-free, GDP-, and GppNHp-bound form. The structure shows a Ras-like G domain between an N-terminal three-helix bundle and a complex system of C-terminal helices and loops. Sequence comparison and secondary structure prediction suggest the IIGP1 structure to be a valid model for the p47 GTPase family. The IIGP1 crystals contain a noncrystallographic dimer. We show that the dimer is required for cooperative GTP hydrolysis and GTP-dependent oligomerization of IIGP1. We also present the GDP- and GppNHp-bound monomeric structures of two dimer interface mutants. Our structures direct approaches to the analysis of the catalytic mechanism of IIGP1 and provide a coherent basis for structure-function studies aimed at elucidating the mechanistic basis of pathogen resistance caused by these enigmatic GTPases.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15350217}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15350217 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15350217}}
==About this Structure==
==About this Structure==
Line 20: Line 24:
==Reference==
==Reference==
Crystal structure of IIGP1: a paradigm for interferon-inducible p47 resistance GTPases., Ghosh A, Uthaiah R, Howard J, Herrmann C, Wolf E, Mol Cell. 2004 Sep 10;15(5):727-39. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15350217 15350217]
Crystal structure of IIGP1: a paradigm for interferon-inducible p47 resistance GTPases., Ghosh A, Uthaiah R, Howard J, Herrmann C, Wolf E, Mol Cell. 2004 Sep 10;15(5):727-39. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15350217 15350217]
 +
 +
IIGP1, an interferon-gamma-inducible 47-kDa GTPase of the mouse, showing cooperative enzymatic activity and GTP-dependent multimerization., Uthaiah RC, Praefcke GJ, Howard JC, Herrmann C, J Biol Chem. 2003 Aug 1;278(31):29336-43. Epub 2003 May 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12732635 12732635]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Single protein]]
Line 32: Line 38:
[[Category: Immunology]]
[[Category: Immunology]]
[[Category: Interferon gamma]]
[[Category: Interferon gamma]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:14:41 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:07:07 2008''

Revision as of 10:07, 28 July 2008

Image:1tq6.png

Template:STRUCTURE 1tq6

Crystal Structure of IIGP1: a paradigm for interferon inducible p47 resistance GTPases

Template:ABSTRACT PUBMED 15350217

About this Structure

1TQ6 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of IIGP1: a paradigm for interferon-inducible p47 resistance GTPases., Ghosh A, Uthaiah R, Howard J, Herrmann C, Wolf E, Mol Cell. 2004 Sep 10;15(5):727-39. PMID:15350217

IIGP1, an interferon-gamma-inducible 47-kDa GTPase of the mouse, showing cooperative enzymatic activity and GTP-dependent multimerization., Uthaiah RC, Praefcke GJ, Howard JC, Herrmann C, J Biol Chem. 2003 Aug 1;278(31):29336-43. Epub 2003 May 5. PMID:12732635

Page seeded by OCA on Mon Jul 28 13:07:07 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1tq6"
Personal tools