2g5h

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2g5h.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2g5h.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2g5h| PDB=2g5h | SCENE= }}
{{STRUCTURE_2g5h| PDB=2g5h | SCENE= }}
-
'''Structure of tRNA-Dependent Amidotransferase GatCAB'''
+
===Structure of tRNA-Dependent Amidotransferase GatCAB===
-
==Overview==
+
<!--
-
The formation of glutaminyl transfer RNA (Gln-tRNA(Gln)) differs among the three domains of life. Most bacteria employ an indirect pathway to produce Gln-tRNA(Gln) by a heterotrimeric glutamine amidotransferase CAB (GatCAB) that acts on the misacylated Glu-tRNA(Gln). Here, we describe a series of crystal structures of intact GatCAB from Staphylococcus aureus in the apo form and in the complexes with glutamine, asparagine, Mn2+, and adenosine triphosphate analog. Two identified catalytic centers for the glutaminase and transamidase reactions are markedly distant but connected by a hydrophilic ammonia channel 30 A in length. Further, we show that the first U-A base pair in the acceptor stem and the D loop of tRNA(Gln) serve as identity elements essential for discrimination by GatCAB and propose a complete model for the overall concerted reactions to synthesize Gln-tRNA(Gln).
+
The line below this paragraph, {{ABSTRACT_PUBMED_16809541}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16809541 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16809541}}
==About this Structure==
==About this Structure==
Line 26: Line 30:
[[Category: Yao, M.]]
[[Category: Yao, M.]]
[[Category: Multi protein complex]]
[[Category: Multi protein complex]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:42:32 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:16:46 2008''

Revision as of 10:16, 28 July 2008

Image:2g5h.png

Template:STRUCTURE 2g5h

Structure of tRNA-Dependent Amidotransferase GatCAB

Template:ABSTRACT PUBMED 16809541

About this Structure

2G5H is a Protein complex structure of sequences from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Ammonia channel couples glutaminase with transamidase reactions in GatCAB., Nakamura A, Yao M, Chimnaronk S, Sakai N, Tanaka I, Science. 2006 Jun 30;312(5782):1954-8. PMID:16809541

Page seeded by OCA on Mon Jul 28 13:16:46 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2g5h"
Personal tools