2vqi

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{{STRUCTURE_2vqi| PDB=2vqi | SCENE= }}
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'''STRUCTURE OF THE P PILUS USHER (PAPC) TRANSLOCATION PORE'''
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===STRUCTURE OF THE P PILUS USHER (PAPC) TRANSLOCATION PORE===
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==Overview==
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Gram-negative pathogens commonly exhibit adhesive pili on their surfaces that mediate specific attachment to the host. A major class of pili is assembled via the chaperone/usher pathway. Here, the structural basis for pilus fiber assembly and secretion performed by the outer membrane assembly platform--the usher--is revealed by the crystal structure of the translocation domain of the P pilus usher PapC and single particle cryo-electron microscopy imaging of the FimD usher bound to a translocating type 1 pilus assembly intermediate. These structures provide molecular snapshots of a twinned-pore translocation machinery in action. Unexpectedly, only one pore is used for secretion, while both usher protomers are used for chaperone-subunit complex recruitment. The translocating pore itself comprises 24 beta strands and is occluded by a folded plug domain, likely gated by a conformationally constrained beta-hairpin. These structures capture the secretion of a virulence factor across the outer membrane of gram-negative bacteria.
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==About this Structure==
==About this Structure==
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[[Category: Transport]]
[[Category: Transport]]
[[Category: Usher]]
[[Category: Usher]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 28 09:16:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:20:53 2008''

Revision as of 10:20, 28 July 2008

Image:2vqi.png

Template:STRUCTURE 2vqi

STRUCTURE OF THE P PILUS USHER (PAPC) TRANSLOCATION PORE

Template:ABSTRACT PUBMED 18485872

About this Structure

2VQI is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Fiber formation across the bacterial outer membrane by the chaperone/usher pathway., Remaut H, Tang C, Henderson NS, Pinkner JS, Wang T, Hultgren SJ, Thanassi DG, Waksman G, Li H, Cell. 2008 May 16;133(4):640-52. PMID:18485872

Page seeded by OCA on Mon Jul 28 13:20:53 2008

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