2r4y

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2r4y.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2r4y.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2r4y| PDB=2r4y | SCENE= }}
{{STRUCTURE_2r4y| PDB=2r4y | SCENE= }}
-
'''Ligand Migration and Binding in The Dimeric Hemoglobin of Scapharca Inaequivalvis: H69V/I114M unliganded'''
+
===Ligand Migration and Binding in The Dimeric Hemoglobin of Scapharca Inaequivalvis: H69V/I114M unliganded===
-
==Overview==
+
<!--
-
Using Fourier transform infrared (FTIR) spectroscopy combined with temperature derivative spectroscopy (TDS) at cryogenic temperatures, we have studied CO binding to the heme and CO migration among cavities in the interior of the dimeric hemoglobin of Scapharca inaequivalvis (HbI) after photodissociation. By combining these studies with X-ray crystallography, three transient ligand docking sites were identified: a primary docking site B in close vicinity to the heme iron, and two secondary docking sites C and D corresponding to the Xe4 and Xe2 cavities of myoglobin. To assess the relevance of these findings for physiological binding, we also performed flash photolysis experiments on HbICO at room temperature and equilibrium binding studies with dioxygen. Our results show that the Xe4 and Xe2 cavities serve as transient docking sites for unbound ligands in the protein, but not as way stations on the entry/exit pathway. For HbI, the so-called histidine gate mechanism proposed for other globins appears as a plausible entry/exit route as well.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18001141}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18001141 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18001141}}
==About this Structure==
==About this Structure==
Line 37: Line 41:
[[Category: Oxygen storage/transport]]
[[Category: Oxygen storage/transport]]
[[Category: Oxygen transport]]
[[Category: Oxygen transport]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:15:03 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:20:56 2008''

Revision as of 10:20, 28 July 2008

Image:2r4y.png

Template:STRUCTURE 2r4y

Ligand Migration and Binding in The Dimeric Hemoglobin of Scapharca Inaequivalvis: H69V/I114M unliganded

Template:ABSTRACT PUBMED 18001141

About this Structure

2R4Y is a Single protein structure of sequence from Scapharca inaequivalvis. Full crystallographic information is available from OCA.

Reference

Ligand migration and binding in the dimeric hemoglobin of Scapharca inaequivalvis., Nienhaus K, Knapp JE, Palladino P, Royer WE Jr, Nienhaus GU, Biochemistry. 2007 Dec 11;46(49):14018-31. Epub 2007 Nov 15. PMID:18001141

Page seeded by OCA on Mon Jul 28 13:20:56 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2r4y"
Personal tools