1soy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1soy.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1soy.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1soy| PDB=1soy | SCENE= }}
{{STRUCTURE_1soy| PDB=1soy | SCENE= }}
-
'''Solution structure of the bacterial frataxin orthologue, CyaY'''
+
===Solution structure of the bacterial frataxin orthologue, CyaY===
-
==Overview==
+
<!--
-
CyaY is the bacterial ortholog of frataxin, a small mitochondrial iron binding protein thought to be involved in iron sulphur cluster formation. Loss of frataxin function leads to the neurodegenerative disorder Friedreich's ataxia. We have solved the solution structure of CyaY and used the structural information to map iron binding onto the protein surface. Comparison of the behavior of wild-type CyaY with that of a mutant indicates that specific binding with a defined stoichiometry does not require aggregation and that the main binding site, which hosts both Fe(2+) and Fe(3+), occupies a highly anionic surface of the molecule. This function is conserved across species since the corresponding region of human frataxin is also able to bind iron, albeit with weaker affinity. The presence of secondary binding sites on CyaY, but not on frataxin, hints at a possible polymerization mechanism. We suggest mutations that may provide further insights into the frataxin function.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15530368}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15530368 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15530368}}
==About this Structure==
==About this Structure==
-
1SOY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SOY OCA].
+
1SOY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SOY OCA].
==Reference==
==Reference==
Line 31: Line 35:
[[Category: Friedreich's ataxia iron binding]]
[[Category: Friedreich's ataxia iron binding]]
[[Category: Nmr]]
[[Category: Nmr]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:58:07 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:23:30 2008''

Revision as of 10:23, 28 July 2008

Image:1soy.png

Template:STRUCTURE 1soy

Solution structure of the bacterial frataxin orthologue, CyaY

Template:ABSTRACT PUBMED 15530368

About this Structure

1SOY is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

Solution structure of the bacterial frataxin ortholog, CyaY: mapping the iron binding sites., Nair M, Adinolfi S, Pastore C, Kelly G, Temussi P, Pastore A, Structure. 2004 Nov;12(11):2037-48. PMID:15530368

Page seeded by OCA on Mon Jul 28 13:23:30 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1soy"
Personal tools