2bhn

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{{STRUCTURE_2bhn| PDB=2bhn | SCENE= }}
{{STRUCTURE_2bhn| PDB=2bhn | SCENE= }}
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'''XPF FROM AEROPYRUM PERNIX'''
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===XPF FROM AEROPYRUM PERNIX===
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==Overview==
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The XPF/Mus81 structure-specific endonucleases cleave double-stranded DNA (dsDNA) within asymmetric branched DNA substrates and play an essential role in nucleotide excision repair, recombination and genome integrity. We report the structure of an archaeal XPF homodimer alone and bound to dsDNA. Superposition of these structures reveals a large domain movement upon binding DNA, indicating how the (HhH)(2) domain and the nuclease domain are coupled to allow the recognition of double-stranded/single-stranded DNA junctions. We identify two nonequivalent DNA-binding sites and propose a model in which XPF distorts the 3' flap substrate in order to engage both binding sites and promote strand cleavage. The model rationalises published biochemical data and implies a novel role for the ERCC1 subunit of eukaryotic XPF complexes.
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{{ABSTRACT_PUBMED_15719018}}
==About this Structure==
==About this Structure==
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[[Category: Nucleotide excision repair]]
[[Category: Nucleotide excision repair]]
[[Category: Structure specific endonuclease]]
[[Category: Structure specific endonuclease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:24:16 2008''

Revision as of 10:24, 28 July 2008

Image:2bhn.png

Template:STRUCTURE 2bhn

XPF FROM AEROPYRUM PERNIX

Template:ABSTRACT PUBMED 15719018

About this Structure

2BHN is a Single protein structure of sequence from Aeropyrum pernix. Full crystallographic information is available from OCA.

Reference

Structure of an XPF endonuclease with and without DNA suggests a model for substrate recognition., Newman M, Murray-Rust J, Lally J, Rudolf J, Fadden A, Knowles PP, White MF, McDonald NQ, EMBO J. 2005 Mar 9;24(5):895-905. Epub 2005 Feb 17. PMID:15719018

Page seeded by OCA on Mon Jul 28 13:24:16 2008

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