1mup
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(New page: 200px<br /><applet load="1mup" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mup, resolution 2.4Å" /> '''PHEROMONE BINDING TO ...)
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Revision as of 19:35, 20 November 2007
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PHEROMONE BINDING TO TWO RODENT URINARY PROTEINS REVEALED BY X-RAY CRYSTALLOGRAPHY
Overview
The principal protein excreted in male rat urine, urinary alpha 2-globulin, and the homologous mouse protein, major urinary protein, have been well, characterized, although their functions remain unclear. Male rat urine, affects the behaviour and sexual response of female rats, leading to the, proposal that rodent urinary proteins are responsible for binding, pheromones and their subsequent release from drying urine. Urinary alpha, 2-globulin is also involved in hyaline droplet nephropathy, an important, toxicological syndrome in male rats resulting from exposure to a number of, industrial chemicals and characterized by the accumulation of liganded, urinary alpha 2-globulin in lysosomes in the kidney, followed by the, induction of renal cancer. We now report the three-dimensional structures, of mouse major urinary protein (at 2.4 A resolution) and rat urinary alpha, 2-globulin (at 2.8 A resolution). The results corroborate the role of, these proteins in pheromone transport and elaborate the structural basis, of ligand binding.
About this Structure
1MUP is a Single protein structure of sequence from Mus musculus with CD and TZL as ligands. Full crystallographic information is available from OCA.
Reference
Pheromone binding to two rodent urinary proteins revealed by X-ray crystallography., Bocskei Z, Groom CR, Flower DR, Wright CE, Phillips SE, Cavaggioni A, Findlay JB, North AC, Nature. 1992 Nov 12;360(6400):186-8. PMID:1279439
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