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2nml

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[[Image:2nml.jpg|left|200px]]
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{{STRUCTURE_2nml| PDB=2nml | SCENE= }}
{{STRUCTURE_2nml| PDB=2nml | SCENE= }}
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'''Crystal structure of HEF2/ERH at 1.55 A resolution'''
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===Crystal structure of HEF2/ERH at 1.55 A resolution===
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==Overview==
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Functional complementation screens can identify known or novel proteins with important intracellular activities. We have isolated human enhancer of filamentation 2 (HEF2) in a screen to find human genes that promote pseudohyphal growth in budding yeast. HEF2 is identical to enhancer of rudimentary homolog (ERH), a highly conserved protein of 104 amino acids. In silico protein-interaction mapping implies that HEF2/ERH interacts with transcription factors, cell-cycle regulators, and other proteins shown to enhance filamentous growth in S. cerevisiae, suggesting a context for studies of HEF2/ERH function. To provide a mechanistic basis to study of HEF2/ERH, we have determined the crystal structure of HEF2/ERH at 1.55 A. The crystal asymmetric unit contains a HEF2/ERH monomer. The two monomers of the physiological dimer are related by the y, x, -z crystal symmetric operation. The HEF2/ERH structure is characterized by a novel alpha + beta fold, a four-strand antiparallel beta-sheet with three alpha-helixes on one side of the sheet. The beta-sheets from the two monomers together constitute a pseudo-beta-barrel, and form the center of the functional HEF2/ERH dimer, with a cavity channel at the dimer interface. Docking of this structure to the HEF2/ERH partner protein DCOH/PCD suggests that HEF2/ERH may regulate the oligomeric state of this protein. These data suggest that HEF2/ERH may be an important transcription regulator that also functions in the control of cell-cycle progression.
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{{ABSTRACT_PUBMED_17444515}}
==About this Structure==
==About this Structure==
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:25:26 2008''

Revision as of 10:25, 28 July 2008

Image:2nml.png

Template:STRUCTURE 2nml

Crystal structure of HEF2/ERH at 1.55 A resolution

Template:ABSTRACT PUBMED 17444515

About this Structure

2NML is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 2i4f. Full crystallographic information is available from OCA.

Reference

A 1.55 A resolution X-ray crystal structure of HEF2/ERH and insights into its transcriptional and cell-cycle interaction networks., Jin T, Guo F, Serebriiskii IG, Howard A, Zhang YZ, Proteins. 2007 Aug 1;68(2):427-37. PMID:17444515

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