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2o5v

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{{STRUCTURE_2o5v| PDB=2o5v | SCENE= }}
{{STRUCTURE_2o5v| PDB=2o5v | SCENE= }}
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'''Recombination mediator RecF'''
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===Recombination mediator RecF===
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==Overview==
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RecF, together with RecO and RecR, belongs to a ubiquitous group of recombination mediators (RMs) that includes eukaryotic proteins such as Rad52 and BRCA2. RMs help maintain genome stability in the presence of DNA damage by loading RecA-like recombinases and displacing single-stranded DNA-binding proteins. Here, we present the crystal structure of RecF from Deinococcus radiodurans. RecF exhibits a high degree of structural similarity with the head domain of Rad50, but lacks its long coiled-coil region. The structural homology between RecF and Rad50 is extensive, encompassing the ATPase subdomain and the so-called 'Lobe II' subdomain of Rad50. The pronounced structural conservation between bacterial RecF and evolutionarily diverged eukaryotic Rad50 implies a conserved mechanism of DNA binding and recognition of the boundaries of double-stranded DNA regions. The RecF structure, mutagenesis of conserved motifs and ATP-dependent dimerization of RecF are discussed with respect to its role in promoting presynaptic complex formation at DNA damage sites.
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(as it appears on PubMed at http://www.pubmed.gov), where 17255941 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17255941}}
==About this Structure==
==About this Structure==
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[[Category: Signature motif]]
[[Category: Signature motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:22:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:25:56 2008''

Revision as of 10:26, 28 July 2008

Image:2o5v.png

Template:STRUCTURE 2o5v

Recombination mediator RecF

Template:ABSTRACT PUBMED 17255941

About this Structure

2O5V is a Single protein structure of sequence from Deinococcus radiodurans. Full crystallographic information is available from OCA.

Reference

Structural conservation of RecF and Rad50: implications for DNA recognition and RecF function., Koroleva O, Makharashvili N, Courcelle CT, Courcelle J, Korolev S, EMBO J. 2007 Feb 7;26(3):867-77. Epub 2007 Jan 25. PMID:17255941

Page seeded by OCA on Mon Jul 28 13:25:56 2008

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