1ryx

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{{STRUCTURE_1ryx| PDB=1ryx | SCENE= }}
{{STRUCTURE_1ryx| PDB=1ryx | SCENE= }}
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'''Crystal structure of hen serum transferrin in apo- form'''
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===Crystal structure of hen serum transferrin in apo- form===
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==Overview==
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The iron binding and release of serum transferrin are pH-dependent and accompanied by a conformational change between the iron-bound (holo-) and iron-free (apo-) forms. We have determined the crystal structure of apo-hen serum transferrin (hAST) at 3.5A resolution, which is the first reported structure to date of any full molecule of an apo-serum transferrin and studied its pH-dependent iron release by UV-vis absorption and near UV-CD spectroscopy. The crystal structure of hAST shows that both the lobes adopt an open conformation and the relative orientations of the domains are different from those of apo-human serum transferrin and human apolactoferrin but similar to that of hen apo-ovotransferrin. Spectroscopic analysis reveals that in hen serum transferrin, release of the first iron starts at a pH approximately 6.5 and continues over a broad pH range (6.5-5.2). The complete release of the iron, however, occurs at pH approximately 4.0. The near UV-CD spectra show alterations in the microenvironment of the aromatic residues surrounding the iron-binding sites.
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{{ABSTRACT_PUBMED_15044101}}
==About this Structure==
==About this Structure==
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[[Category: Domain orientation]]
[[Category: Domain orientation]]
[[Category: Hen serum transferrin]]
[[Category: Hen serum transferrin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:04:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:27:10 2008''

Revision as of 10:27, 28 July 2008

Image:1ryx.png

Template:STRUCTURE 1ryx

Crystal structure of hen serum transferrin in apo- form

Template:ABSTRACT PUBMED 15044101

About this Structure

1RYX is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

Tertiary structural changes associated with iron binding and release in hen serum transferrin: a crystallographic and spectroscopic study., Thakurta PG, Choudhury D, Dasgupta R, Dattagupta JK, Biochem Biophys Res Commun. 2004 Apr 16;316(4):1124-31. PMID:15044101

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