2a20

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[[Image:2a20.gif|left|200px]]
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{{Seed}}
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[[Image:2a20.png|left|200px]]
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{{STRUCTURE_2a20| PDB=2a20 | SCENE= }}
{{STRUCTURE_2a20| PDB=2a20 | SCENE= }}
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'''Solution structure of Rim2 Zinc Finger Domain'''
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===Solution structure of Rim2 Zinc Finger Domain===
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==Overview==
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alpha-RIMs and Munc13s are active zone proteins that control priming of synaptic vesicles to a readily releasable state, and interact with each other via their N-terminal sequences. The alpha-RIM N-terminal sequence also binds to Rab3s (small synaptic vesicle GTPases), an interaction that regulates presynaptic plasticity. We now demonstrate that alpha-RIMs contain adjacent but separate Munc13- and Rab3-binding sites, allowing formation of a tripartite Rab3/RIM/Munc13 complex. Munc13 binding is mediated by the alpha-RIM zinc-finger domain. Elucidation of the three-dimensional structure of this domain by NMR spectroscopy facilitated the design of a mutation that abolishes alpha-RIM/Munc13 binding. Selective disruption of this interaction in the calyx of Held synapse decreased the size of the readily releasable vesicle pool. Our data suggest that the ternary Rab3/RIM/Munc13 interaction approximates synaptic vesicles to the priming machinery, providing a substrate for presynaptic plasticity. The modular architecture of alpha-RIMs, with nested binding sites for Rab3 and other targets, may be a general feature of Rab effectors that share homology with the alpha-RIM N-terminal sequence.
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The line below this paragraph, {{ABSTRACT_PUBMED_16052212}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16052212 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16052212}}
==About this Structure==
==About this Structure==
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2A20 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A20 OCA].
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2A20 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A20 OCA].
==Reference==
==Reference==
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[[Category: Sudhof, T C.]]
[[Category: Sudhof, T C.]]
[[Category: Zinc-finger domain]]
[[Category: Zinc-finger domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:30:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:37:00 2008''

Revision as of 10:37, 28 July 2008

Image:2a20.png

Template:STRUCTURE 2a20

Solution structure of Rim2 Zinc Finger Domain

Template:ABSTRACT PUBMED 16052212

About this Structure

2A20 is a Single protein structure of sequence from Rattus norvegicus. Full experimental information is available from OCA.

Reference

A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?, Dulubova I, Lou X, Lu J, Huryeva I, Alam A, Schneggenburger R, Sudhof TC, Rizo J, EMBO J. 2005 Aug 17;24(16):2839-50. Epub 2005 Jul 28. PMID:16052212

Page seeded by OCA on Mon Jul 28 13:37:00 2008

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