2oox

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{{STRUCTURE_2oox| PDB=2oox | SCENE= }}
{{STRUCTURE_2oox| PDB=2oox | SCENE= }}
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'''Crystal structure of the adenylate sensor from AMP-activated protein kinase complexed with AMP'''
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===Crystal structure of the adenylate sensor from AMP-activated protein kinase complexed with AMP===
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==Overview==
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The 5'-AMP (adenosine monophosphate)-activated protein kinase (AMPK) coordinates metabolic function with energy availability by responding to changes in intracellular ATP (adenosine triphosphate) and AMP concentrations. Here, we report crystal structures at 2.9 and 2.6 A resolution for ATP- and AMP-bound forms of a core alphabetagamma adenylate-binding domain from the fission yeast AMPK homolog. ATP and AMP bind competitively to a single site in the gamma subunit, with their respective phosphate groups positioned near function-impairing mutants. Unexpectedly, ATP binds without counterions, amplifying its electrostatic effects on a critical regulatory region where all three subunits converge.
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(as it appears on PubMed at http://www.pubmed.gov), where 17289942 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17289942}}
==About this Structure==
==About this Structure==
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[[Category: Crystal structure]]
[[Category: Crystal structure]]
[[Category: Kinase]]
[[Category: Kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:21:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:42:44 2008''

Revision as of 10:42, 28 July 2008

Image:2oox.png

Template:STRUCTURE 2oox

Crystal structure of the adenylate sensor from AMP-activated protein kinase complexed with AMP

Template:ABSTRACT PUBMED 17289942

About this Structure

2OOX is a Protein complex structure of sequences from Schizosaccharomyces pombe. Full crystallographic information is available from OCA.

Reference

Crystal structures of the adenylate sensor from fission yeast AMP-activated protein kinase., Townley R, Shapiro L, Science. 2007 Mar 23;315(5819):1726-9. Epub 2007 Feb 8. PMID:17289942

Page seeded by OCA on Mon Jul 28 13:42:44 2008

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