1og5

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[[Image:1og5.gif|left|200px]]
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{{STRUCTURE_1og5| PDB=1og5 | SCENE= }}
{{STRUCTURE_1og5| PDB=1og5 | SCENE= }}
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'''STRUCTURE OF HUMAN CYTOCHROME P450 CYP2C9'''
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===STRUCTURE OF HUMAN CYTOCHROME P450 CYP2C9===
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==Overview==
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Cytochrome P450 proteins (CYP450s) are membrane-associated haem proteins that metabolize physiologically important compounds in many species of microorganisms, plants and animals. Mammalian CYP450s recognize and metabolize diverse xenobiotics such as drug molecules, environmental compounds and pollutants. Human CYP450 proteins CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 are the major drug-metabolizing isoforms, and contribute to the oxidative metabolism of more than 90% of the drugs in current clinical use. Polymorphic variants have also been reported for some CYP450 isoforms, which has implications for the efficacy of drugs in individuals, and for the co-administration of drugs. The molecular basis of drug recognition by human CYP450s, however, has remained elusive. Here we describe the crystal structure of a human CYP450, CYP2C9, both unliganded and in complex with the anti-coagulant drug warfarin. The structure defines unanticipated interactions between CYP2C9 and warfarin, and reveals a new binding pocket. The binding mode of warfarin suggests that CYP2C9 may undergo an allosteric mechanism during its function. The newly discovered binding pocket also suggests that CYP2C9 may simultaneously accommodate multiple ligands during its biological function, and provides a possible molecular basis for understanding complex drug-drug interactions.
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(as it appears on PubMed at http://www.pubmed.gov), where 12861225 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12861225}}
==About this Structure==
==About this Structure==
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[[Category: Drug metabolism,electron transport,oxidoreductase,heme]]
[[Category: Drug metabolism,electron transport,oxidoreductase,heme]]
[[Category: Monooxygenase]]
[[Category: Monooxygenase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:48:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:44:28 2008''

Revision as of 10:44, 28 July 2008

Image:1og5.png

Template:STRUCTURE 1og5

STRUCTURE OF HUMAN CYTOCHROME P450 CYP2C9

Template:ABSTRACT PUBMED 12861225

About this Structure

1OG5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human cytochrome P450 2C9 with bound warfarin., Williams PA, Cosme J, Ward A, Angove HC, Matak Vinkovic D, Jhoti H, Nature. 2003 Jul 24;424(6947):464-8. Epub 2003 Jul 13. PMID:12861225

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