1s76

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[[Image:1s76.gif|left|200px]]
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{{Seed}}
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[[Image:1s76.png|left|200px]]
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{{STRUCTURE_1s76| PDB=1s76 | SCENE= }}
{{STRUCTURE_1s76| PDB=1s76 | SCENE= }}
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'''T7 RNA polymerase alpha beta methylene ATP elongation complex'''
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===T7 RNA polymerase alpha beta methylene ATP elongation complex===
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==Overview==
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RNA polymerase functions like a molecular motor that can convert chemical energy into the work of strand separation and translocation along the DNA during transcription. The structures of phage T7 RNA polymerase in an elongation phase substrate complex that includes the incoming nucleoside triphosphate and a pretranslocation product complex that includes the product pyrophosphate (PPi) are described here. These structures and the previously determined posttranslocation elongation complex demonstrate that two enzyme conformations exist during a cycle of single nucleotide addition. One orientation of a five-helix subdomain is stabilized by the phosphates of either the incoming NTP or by the product PPi. A second orientation of this subdomain is stable in their absence and is associated with translocation of the heteroduplex product as well as strand separation of the downstream DNA. We propose that the dissociation of the product PPi after nucleotide addition produces the protein conformational change resulting in translocation and strand separation.
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The line below this paragraph, {{ABSTRACT_PUBMED_15016374}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15016374 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15016374}}
==About this Structure==
==About this Structure==
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[[Category: Yin, Y W.]]
[[Category: Yin, Y W.]]
[[Category: T7 rna polymerase]]
[[Category: T7 rna polymerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:22:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:45:28 2008''

Revision as of 10:45, 28 July 2008

Image:1s76.png

Template:STRUCTURE 1s76

T7 RNA polymerase alpha beta methylene ATP elongation complex

Template:ABSTRACT PUBMED 15016374

About this Structure

1S76 is a Single protein structure of sequence from Enterobacteria phage t7. Full crystallographic information is available from OCA.

Reference

The structural mechanism of translocation and helicase activity in T7 RNA polymerase., Yin YW, Steitz TA, Cell. 2004 Feb 6;116(3):393-404. PMID:15016374

Page seeded by OCA on Mon Jul 28 13:45:28 2008

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