1yuk

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[[Image:1yuk.gif|left|200px]]
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{{STRUCTURE_1yuk| PDB=1yuk | SCENE= }}
{{STRUCTURE_1yuk| PDB=1yuk | SCENE= }}
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'''The crystal structure of the PSI/Hybrid domain/ I-EGF1 segment from the human integrin beta2 at 1.8 resolution'''
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===The crystal structure of the PSI/Hybrid domain/ I-EGF1 segment from the human integrin beta2 at 1.8 resolution===
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==Overview==
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Integrins are modular (alphabeta) heterodimeric proteins that mediate cell adhesion and convey signals across the plasma membrane. Interdomain motions play a key role in signal transduction by propagating structural changes through the molecule, thus controlling the activation state and adhesive properties of the integrin. We expressed a soluble fragment of the human integrin beta2 subunit comprising the plexin-semaphorin-integrin domain (PSI)/hybrid domain/I-EGF1 fragment and present its crystal structure at 1.8-A resolution. The structure reveals an elongated molecule with a rigid architecture stabilized by nine disulfide bridges. The PSI domain is located centrally and participates in the formation of extended interfaces with the hybrid domain and I-EGF1 domains, respectively. The hybrid domain/PSI interface involves the burial of an Arg residue, and contacts between PSI and I-EGF1 are mainly mediated by well conserved Arg and Trp residues. Conservation of key interacting residues across the various integrin beta subunits sequences suggests that our structure represents a good model for the entire integrin family. Superposition with the integrin beta3 receptor in its bent conformation suggests that an articulation point is present at the linkage between its I-EGF1 and I-EGF2 modules and underlines the importance of this region for the control of integrin-mediated cell adhesion.
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The line below this paragraph, {{ABSTRACT_PUBMED_15965234}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15965234 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15965234}}
==About this Structure==
==About this Structure==
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[[Category: Integrin beta2]]
[[Category: Integrin beta2]]
[[Category: Psi domain]]
[[Category: Psi domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:48:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:45:39 2008''

Revision as of 10:45, 28 July 2008

Image:1yuk.png

Template:STRUCTURE 1yuk

The crystal structure of the PSI/Hybrid domain/ I-EGF1 segment from the human integrin beta2 at 1.8 resolution

Template:ABSTRACT PUBMED 15965234

About this Structure

1YUK is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of the plexin-semaphorin-integrin domain/hybrid domain/I-EGF1 segment from the human integrin beta2 subunit at 1.8-A resolution., Shi M, Sundramurthy K, Liu B, Tan SM, Law SK, Lescar J, J Biol Chem. 2005 Aug 26;280(34):30586-93. Epub 2005 Jun 17. PMID:15965234

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