1z9m

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{{STRUCTURE_1z9m| PDB=1z9m | SCENE= }}
{{STRUCTURE_1z9m| PDB=1z9m | SCENE= }}
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'''Crystal Structure of Nectin-like molecule-1 protein Domain 1'''
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===Crystal Structure of Nectin-like molecule-1 protein Domain 1===
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==Overview==
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Nectins are Ca(2+)-independent immunoglobulin (Ig) superfamily proteins that participate in the organization of epithelial and endothelial junctions. Nectins have three Ig-like domains in the extracellular region, and the first one is essential in cell-cell adhesion and plays a central role in the interaction with the envelope glycoprotein D of several viruses. Five Nectin-like molecules (Necl-1 through -5) with similar domain structures to those of Nectins have been identified. Necl-1 is specifically expressed in neural tissue, has Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity, and plays an important role in the formation of synapses, axon bundles, and myelinated axons. Here we report the first crystal structure of its N-terminal Ig-like V domain at 2.4 A, providing insight into trans-cellular recognition mediated by Necl-1. The protein crystallized as a dimer, and the dimeric form was confirmed by size-exclusion chromatography and chemical cross-linking experiments, indicating this V domain is sufficient for homophilic interaction. Mutagenesis work demonstrated that Phe(82) is a key residue for the adhesion activity of Necl-1. A model for homophilic adhesion of Necl-1 at synapses is proposed based on its structure and previous studies.
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(as it appears on PubMed at http://www.pubmed.gov), where 16467305 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16467305}}
==About this Structure==
==About this Structure==
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[[Category: Nectin-like]]
[[Category: Nectin-like]]
[[Category: V domain]]
[[Category: V domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:21:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:46:00 2008''

Revision as of 10:46, 28 July 2008

Image:1z9m.png

Template:STRUCTURE 1z9m

Crystal Structure of Nectin-like molecule-1 protein Domain 1

Template:ABSTRACT PUBMED 16467305

About this Structure

1Z9M is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the V domain of human Nectin-like molecule-1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule., Dong X, Xu F, Gong Y, Gao J, Lin P, Chen T, Peng Y, Qiang B, Yuan J, Peng X, Rao Z, J Biol Chem. 2006 Apr 14;281(15):10610-7. Epub 2006 Feb 7. PMID:16467305

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