2c6a

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{{STRUCTURE_2c6a| PDB=2c6a | SCENE= }}
{{STRUCTURE_2c6a| PDB=2c6a | SCENE= }}
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'''SOLUTION STRUCTURE OF THE C4 ZINC-FINGER DOMAIN OF HDM2'''
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===SOLUTION STRUCTURE OF THE C4 ZINC-FINGER DOMAIN OF HDM2===
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==Overview==
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HDM2 is a ubiquitin E3 ligase that is a key negative regulator of the tumor suppressor p53. Here, we report the determination of the solution structure of the C4 zinc finger domain of HDM2 using multidimensional NMR. The HDM2 C4 zinc finger domain has a fold consisting of a 3(10) helix followed by four beta-strands, which shares significant structural similarity to the zinc ribbon protein family. Family based sequence analysis identified two putative binding sites, one of which resembles an RNA binding motif.
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{{ABSTRACT_PUBMED_16385008}}
==About this Structure==
==About this Structure==
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2C6A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C6A OCA].
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2C6A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C6A OCA].
==Reference==
==Reference==
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[[Category: Zinc]]
[[Category: Zinc]]
[[Category: Zinc finger]]
[[Category: Zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:19:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:56:13 2008''

Revision as of 10:56, 28 July 2008

Image:2c6a.png

Template:STRUCTURE 2c6a

SOLUTION STRUCTURE OF THE C4 ZINC-FINGER DOMAIN OF HDM2

Template:ABSTRACT PUBMED 16385008

About this Structure

2C6A is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the C4 zinc finger domain of HDM2., Yu GW, Allen MD, Andreeva A, Fersht AR, Bycroft M, Protein Sci. 2006 Feb;15(2):384-9. Epub 2005 Dec 29. PMID:16385008

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