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1o6v

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[[Image:1o6v.gif|left|200px]]
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{{Seed}}
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[[Image:1o6v.png|left|200px]]
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{{STRUCTURE_1o6v| PDB=1o6v | SCENE= }}
{{STRUCTURE_1o6v| PDB=1o6v | SCENE= }}
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'''INTERNALIN (INLA,LISTERIA MONOCYTOGENES)- FUNCTIONAL DOMAIN UNCOMPLEXED'''
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===INTERNALIN (INLA,LISTERIA MONOCYTOGENES)- FUNCTIONAL DOMAIN UNCOMPLEXED===
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==Overview==
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Listeria monocytogenes, a food-borne bacterial pathogen, enters mammalian cells by inducing its own phagocytosis. The listerial protein internalin (InlA) mediates bacterial adhesion and invasion of epithelial cells in the human intestine through specific interaction with its host cell receptor E-cadherin. We present the crystal structures of the functional domain of InlA alone and in a complex with the extracellular, N-terminal domain of human E-cadherin (hEC1). The leucine rich repeat (LRR) domain of InlA surrounds and specifically recognizes hEC1. Individual interactions were probed by mutagenesis and analytical ultracentrifugation. These include Pro16 of hEC1, a major determinant for human susceptibility to L. monocytogenes infection that is essential for intermolecular recognition. Our studies reveal the structural basis for host tro-pism of this bacterium and the molecular deception L. monocytogenes employs to exploit the E-cadherin system.
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The line below this paragraph, {{ABSTRACT_PUBMED_12526809}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12526809 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12526809}}
==About this Structure==
==About this Structure==
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[[Category: Extracellular recognition]]
[[Category: Extracellular recognition]]
[[Category: Leucine rich repeat]]
[[Category: Leucine rich repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:27:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:56:42 2008''

Revision as of 10:56, 28 July 2008

Image:1o6v.png

Template:STRUCTURE 1o6v

INTERNALIN (INLA,LISTERIA MONOCYTOGENES)- FUNCTIONAL DOMAIN UNCOMPLEXED

Template:ABSTRACT PUBMED 12526809

About this Structure

1O6V is a Single protein structure of sequence from Listeria monocytogenes. Full crystallographic information is available from OCA.

Reference

Structure of internalin, a major invasion protein of Listeria monocytogenes, in complex with its human receptor E-cadherin., Schubert WD, Urbanke C, Ziehm T, Beier V, Machner MP, Domann E, Wehland J, Chakraborty T, Heinz DW, Cell. 2002 Dec 13;111(6):825-36. PMID:12526809

Page seeded by OCA on Mon Jul 28 13:56:42 2008

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