2du2

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{{STRUCTURE_2du2| PDB=2du2 | SCENE= }}
{{STRUCTURE_2du2| PDB=2du2 | SCENE= }}
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'''Crystal Structure Analysis of the L-Lactate Oxidase'''
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===Crystal Structure Analysis of the L-Lactate Oxidase===
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==Overview==
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L-Lactate oxidase (LOX) from Aerococcus viridans is a member of the alpha-hydroxyacid-oxidase flavoenzyme family. We have determined the three-dimensional structure of LOX and revealed the mechanism of substrate recognition. The LOX monomer structure has a typical alpha(8)/beta(8) motif commonly found in other flavin family proteins. A related enzyme, glycolate oxidase, catalyzes the oxidation of glycolate rather than lactate. Comparison of the two enzyme structures highlights the importance of five residues around the FMN prosthetic group of LOX, which act synergistically to discriminate between the l/d configurations of lactate. X-ray crystallography of LOX gave a space group I422 of unit-cell parameters a=b=191.096A, c=194.497A and alpha=beta=gamma=90 degrees with four monomers per asymmetric unit. The four independent monomers display slight structural differences around the active site. Diffraction data were collected, under cryogenic conditions to 2.1A resolution at the synchrotron facilities in Japan.
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{{ABSTRACT_PUBMED_17007814}}
==About this Structure==
==About this Structure==
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:59:56 2008''

Revision as of 10:59, 28 July 2008

Image:2du2.png

Template:STRUCTURE 2du2

Crystal Structure Analysis of the L-Lactate Oxidase

Template:ABSTRACT PUBMED 17007814

About this Structure

2DU2 is a Single protein structure of sequence from Aerococcus viridans. Full crystallographic information is available from OCA.

Reference

The crystal structure of L-lactate oxidase from Aerococcus viridans at 2.1A resolution reveals the mechanism of strict substrate recognition., Umena Y, Yorita K, Matsuoka T, Kita A, Fukui K, Morimoto Y, Biochem Biophys Res Commun. 2006 Nov 17;350(2):249-56. Epub 2006 Sep 18. PMID:17007814

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