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1ocn

From Proteopedia

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{{STRUCTURE_1ocn| PDB=1ocn | SCENE= }}
{{STRUCTURE_1ocn| PDB=1ocn | SCENE= }}
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'''MUTANT D416A OF THE CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS IN COMPLEX WITH A CELLOBIO-DERIVED ISOFAGOMINE AT 1.3 ANGSTROM RESOLUTION'''
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===MUTANT D416A OF THE CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS IN COMPLEX WITH A CELLOBIO-DERIVED ISOFAGOMINE AT 1.3 ANGSTROM RESOLUTION===
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==Overview==
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A cellobio-derived isofagomine glycosidase inhibitor (Ki approximately 400 nM) displays an unusual distorted 2,5B (boat) conformation upon binding to cellobiohydrolase Cel6A from Humicola insolens, highlighting the different conformational itineraries used by various glycosidases, with consequences for the design of therapeutic agents.
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(as it appears on PubMed at http://www.pubmed.gov), where 12744312 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12744312}}
==About this Structure==
==About this Structure==
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[[Category: Glycoside hydrolase family 6]]
[[Category: Glycoside hydrolase family 6]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:40:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:02:58 2008''

Revision as of 11:03, 28 July 2008

Image:1ocn.png

Template:STRUCTURE 1ocn

MUTANT D416A OF THE CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS IN COMPLEX WITH A CELLOBIO-DERIVED ISOFAGOMINE AT 1.3 ANGSTROM RESOLUTION

Template:ABSTRACT PUBMED 12744312

About this Structure

1OCN is a Single protein structure of sequence from Humicola insolens. Full crystallographic information is available from OCA.

Reference

Distortion of a cellobio-derived isofagomine highlights the potential conformational itinerary of inverting beta-glucosidases., Varrot A, Macdonald J, Stick RV, Pell G, Gilbert HJ, Davies GJ, Chem Commun (Camb). 2003 Apr 21;(8):946-7. PMID:12744312

Page seeded by OCA on Mon Jul 28 14:02:58 2008

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