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1xj9

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{{STRUCTURE_1xj9| PDB=1xj9 | SCENE= }}
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'''Crystal structure of a partly self-complementary peptide nucleic acid (PNA) oligomer showing a duplex-triplex network'''
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===Crystal structure of a partly self-complementary peptide nucleic acid (PNA) oligomer showing a duplex-triplex network===
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==Overview==
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The X-ray structure of a partly self-complementary peptide nucleic acid (PNA) decamer (H-GTAGATCACT-l-Lys-NH(2)) to 2.60 A resolution is reported. The structure is mainly controlled by the canonical Watson-Crick base pairs formed by the self-complementary stretch of four bases in the middle of the decamer (G(4)A(5)T(6)C(7)). One right- and one left-handed Watson-Crick duplex are formed. The two PNA units C(9)T(10) change helical handedness, so that each PNA strand contains both a right- and a left-handed section. The changed handedness in C(9)T(10) allows formation of Hoogsteen hydrogen bonding between C(9)T(10) and G(4)A(5) of a PNA strand in an adjacent Watson-Crick double helix of the same handedness. Thereby, a PNA-PNA-PNA triplex is formed. The PNA unit A(3) forms a noncanonical base pair with A(8) in a symmetry-related strand of opposite handedness; the base pair is of the A-A reverse Hoogsteen type. The structural diversity of this PNA demonstrates how the PNA backbone is able to adapt to structures governed by the stacking and hydrogen-bonding interactions between the nucleobases. The crystal structure further shows how PNA oligomers containing limited sequence complementarity may form complex hydrogen-bonding networks.
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{{ABSTRACT_PUBMED_15686374}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Crystal structure of a partly self-complementary peptide nucleic acid (PNA) oligomer showing a duplex-triplex network., Petersson B, Nielsen BB, Rasmussen H, Larsen IK, Gajhede M, Nielsen PE, Kastrup JS, J Am Chem Soc. 2005 Feb 9;127(5):1424-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15686374 15686374]
Crystal structure of a partly self-complementary peptide nucleic acid (PNA) oligomer showing a duplex-triplex network., Petersson B, Nielsen BB, Rasmussen H, Larsen IK, Gajhede M, Nielsen PE, Kastrup JS, J Am Chem Soc. 2005 Feb 9;127(5):1424-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15686374 15686374]
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Crystal structure of a peptide nucleic acid (PNA) duplex at 1.7 A resolution., Rasmussen H, Kastrup JS, Nielsen JN, Nielsen JM, Nielsen PE, Nat Struct Biol. 1997 Feb;4(2):98-101. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9033585 9033585]
[[Category: Gajhede, M.]]
[[Category: Gajhede, M.]]
[[Category: Kastrup, J S.]]
[[Category: Kastrup, J S.]]
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[[Category: Pna]]
[[Category: Pna]]
[[Category: Right-handed]]
[[Category: Right-handed]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:06:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:03:13 2008''

Revision as of 11:03, 28 July 2008

Image:1xj9.png

Template:STRUCTURE 1xj9

Crystal structure of a partly self-complementary peptide nucleic acid (PNA) oligomer showing a duplex-triplex network

Template:ABSTRACT PUBMED 15686374

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of a partly self-complementary peptide nucleic acid (PNA) oligomer showing a duplex-triplex network., Petersson B, Nielsen BB, Rasmussen H, Larsen IK, Gajhede M, Nielsen PE, Kastrup JS, J Am Chem Soc. 2005 Feb 9;127(5):1424-30. PMID:15686374

Crystal structure of a peptide nucleic acid (PNA) duplex at 1.7 A resolution., Rasmussen H, Kastrup JS, Nielsen JN, Nielsen JM, Nielsen PE, Nat Struct Biol. 1997 Feb;4(2):98-101. PMID:9033585

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