2byh

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{{STRUCTURE_2byh| PDB=2byh | SCENE= }}
{{STRUCTURE_2byh| PDB=2byh | SCENE= }}
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'''3-(5-CHLORO-2,4-DIHYDROXYPHENYL)-PYRAZOLE-4-CARBOXAMIDES AS INHIBITORS OF THE HSP90 MOLECULAR CHAPERONE'''
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===3-(5-CHLORO-2,4-DIHYDROXYPHENYL)-PYRAZOLE-4-CARBOXAMIDES AS INHIBITORS OF THE HSP90 MOLECULAR CHAPERONE===
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==Overview==
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Information from X-ray crystal structures of Hsp90 inhibitors bound to the human Hsp90 molecular chaperone was used to assist in the design of 3-(5-chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as novel inhibitors of Hsp90. Accessing an extra interaction with the protein via Phe138 gave a significant increase in binding potency compared to similar analogues that do not make this interaction.
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(as it appears on PubMed at http://www.pubmed.gov), where 16213716 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16213716}}
==About this Structure==
==About this Structure==
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[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
[[Category: Pyrazole]]
[[Category: Pyrazole]]
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Revision as of 11:09, 28 July 2008

Image:2byh.png

Template:STRUCTURE 2byh

3-(5-CHLORO-2,4-DIHYDROXYPHENYL)-PYRAZOLE-4-CARBOXAMIDES AS INHIBITORS OF THE HSP90 MOLECULAR CHAPERONE

Template:ABSTRACT PUBMED 16213716

About this Structure

2BYH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

3-(5-Chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as inhibitors of the Hsp90 molecular chaperone., Brough PA, Barril X, Beswick M, Dymock BW, Drysdale MJ, Wright L, Grant K, Massey A, Surgenor A, Workman P, Bioorg Med Chem Lett. 2005 Dec 1;15(23):5197-201. Epub 2005 Oct 5. PMID:16213716

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