We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

2b9o

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2b9o.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2b9o.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2b9o| PDB=2b9o | SCENE= }}
{{STRUCTURE_2b9o| PDB=2b9o | SCENE= }}
-
'''30S ribosomal subunit, tRNAs and mRNA from a crystal structure of the whole ribosomal complex with a stop codon in the A-site. This file contains the 30S subunit, tRNAs and mRNA from a crystal structure of the whole ribosomal complex with a stop codon in the A-site and is described in remark 400.'''
+
===30S ribosomal subunit, tRNAs and mRNA from a crystal structure of the whole ribosomal complex with a stop codon in the A-site. This file contains the 30S subunit, tRNAs and mRNA from a crystal structure of the whole ribosomal complex with a stop codon in the A-site and is described in remark 400.===
-
==Overview==
+
<!--
-
During protein synthesis, translational release factors catalyze the release of the polypeptide chain when a stop codon on the mRNA reaches the A site of the ribosome. The detailed mechanism of this process is currently unknown. We present here the crystal structures of the ribosome from Thermus thermophilus with RF1 and RF2 bound to their cognate stop codons, at resolutions of 5.9 Angstrom and 6.7 Angstrom, respectively. The structures reveal details of interactions of the factors with the ribosome and mRNA, including elements previously implicated in decoding and peptide release. They also shed light on conformational changes both in the factors and in the ribosome during termination. Differences seen in the interaction of RF1 and RF2 with the L11 region of the ribosome allow us to rationalize previous biochemical data. Finally, this work demonstrates the feasibility of crystallizing ribosomes with bound factors at a defined state along the translational pathway.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16377566}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16377566 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16377566}}
==About this Structure==
==About this Structure==
Line 34: Line 38:
[[Category: Ribosome]]
[[Category: Ribosome]]
[[Category: Translation]]
[[Category: Translation]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:01:20 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:12:00 2008''

Revision as of 11:12, 28 July 2008

Image:2b9o.png

Template:STRUCTURE 2b9o

30S ribosomal subunit, tRNAs and mRNA from a crystal structure of the whole ribosomal complex with a stop codon in the A-site. This file contains the 30S subunit, tRNAs and mRNA from a crystal structure of the whole ribosomal complex with a stop codon in the A-site and is described in remark 400.

Template:ABSTRACT PUBMED 16377566

About this Structure

2B9O is a Protein complex structure of sequences from Escherichia coli, Thermus thermophilus and Thermus thermophilus hb8. Full crystallographic information is available from OCA.

Reference

Crystal structures of the ribosome in complex with release factors RF1 and RF2 bound to a cognate stop codon., Petry S, Brodersen DE, Murphy FV 4th, Dunham CM, Selmer M, Tarry MJ, Kelley AC, Ramakrishnan V, Cell. 2005 Dec 29;123(7):1255-66. PMID:16377566

Page seeded by OCA on Mon Jul 28 14:12:00 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2b9o"
Personal tools