1wrd

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1wrd.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1wrd.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1wrd| PDB=1wrd | SCENE= }}
{{STRUCTURE_1wrd| PDB=1wrd | SCENE= }}
-
'''Crystal structure of Tom1 GAT domain in complex with ubiquitin'''
+
===Crystal structure of Tom1 GAT domain in complex with ubiquitin===
-
==Overview==
+
<!--
-
Tom1 (Target of Myb1) is suggested to be involved in the transport of ubiquitinated proteins, through the interaction of its GAT (GGA and Tom1) domain with ubiquitin. Here, we demonstrate that the three-helix bundle of Tom1-GAT has two ubiquitin-binding sites recognizing the hydrophobic Ile44 surface of ubiquitin. The complex crystal structure demonstrates that the first site is a hydrophobic patch on helices alpha1 and alpha2. NMR and biochemical data revealed that the N-terminal half of helix alpha3 of Tom1-GAT constitutes the second, stronger binding site. The double-sided ubiquitin binding enhances the efficiency of recognition of ubiquitinated proteins by Tom1.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16199040}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16199040 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16199040}}
==About this Structure==
==About this Structure==
Line 34: Line 38:
[[Category: Three-helix bundle]]
[[Category: Three-helix bundle]]
[[Category: Ubiquitin-binding protein]]
[[Category: Ubiquitin-binding protein]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:02:45 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:16:15 2008''

Revision as of 11:16, 28 July 2008

Image:1wrd.png

Template:STRUCTURE 1wrd

Crystal structure of Tom1 GAT domain in complex with ubiquitin

Template:ABSTRACT PUBMED 16199040

About this Structure

1WRD is a Protein complex structure of sequences from Bos taurus and Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for recognition of ubiquitinated cargo by Tom1-GAT domain., Akutsu M, Kawasaki M, Katoh Y, Shiba T, Yamaguchi Y, Kato R, Kato K, Nakayama K, Wakatsuki S, FEBS Lett. 2005 Oct 10;579(24):5385-91. PMID:16199040

Page seeded by OCA on Mon Jul 28 14:16:15 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1wrd"
Personal tools