1x7a

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[[Image:1x7a.gif|left|200px]]
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{{STRUCTURE_1x7a| PDB=1x7a | SCENE= }}
{{STRUCTURE_1x7a| PDB=1x7a | SCENE= }}
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'''Porcine Factor IXa Complexed to 1-{3-[amino(imino)methyl]phenyl}-N-[4-(1H-benzimidazol-1-yl)-2-fluorophenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide'''
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===Porcine Factor IXa Complexed to 1-{3-[amino(imino)methyl]phenyl}-N-[4-(1H-benzimidazol-1-yl)-2-fluorophenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide===
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==Overview==
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Modifications to the P4 moiety and pyrazole C3 substituent of factor Xa inhibitor SN-429 provided several new compounds, which are 5-10nM inhibitors of factor IXa. An X-ray crystal structure of one example complexed to factor IXa shows that these compounds adopt a similar binding mode to that previously observed with pyrazole inhibitors in the factor Xa active site both with regard to how the inhibitor binds and the position of Tyr99.
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(as it appears on PubMed at http://www.pubmed.gov), where 15454208 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15454208}}
==About this Structure==
==About this Structure==
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[[Category: Inhibition]]
[[Category: Inhibition]]
[[Category: X-ray structure]]
[[Category: X-ray structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:39:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:20:13 2008''

Revision as of 11:20, 28 July 2008

Image:1x7a.png

Template:STRUCTURE 1x7a

Porcine Factor IXa Complexed to 1-{3-[amino(imino)methyl]phenyl}-N-[4-(1H-benzimidazol-1-yl)-2-fluorophenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Template:ABSTRACT PUBMED 15454208

About this Structure

1X7A is a Protein complex structure of sequences from Sus scrofa. Full crystallographic information is available from OCA.

Reference

SAR and factor IXa crystal structure of a dual inhibitor of factors IXa and Xa., Smallheer JM, Alexander RS, Wang J, Wang S, Nakajima S, Rossi KA, Smallwood A, Barbera F, Burdick D, Luettgen JM, Knabb RM, Wexler RR, Jadhav PK, Bioorg Med Chem Lett. 2004 Nov 1;14(21):5263-7. PMID:15454208

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