1na0

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{{STRUCTURE_1na0| PDB=1na0 | SCENE= }}
{{STRUCTURE_1na0| PDB=1na0 | SCENE= }}
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'''Design of Stable alpha-Helical Arrays from an Idealized TPR Motif'''
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===Design of Stable alpha-Helical Arrays from an Idealized TPR Motif===
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==Overview==
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The tetratricopeptide repeat (TPR) is a 34-amino acid alpha-helical motif that occurs in over 300 different proteins. In the different proteins, three to sixteen or more TPR motifs occur in tandem arrays and function to mediate protein-protein interactions. The binding specificity of each TPR protein is different, although the underlying structural motif is the same. Here we describe a statistical approach to the design of an idealized TPR motif. We present the high-resolution X-ray crystal structures (to 1.55 and 1.6 A) of designed TPR proteins and describe their solution properties and stability. A detailed analysis of these structures provides an understanding of the TPR motif, how it is repeated to give helical arrays with different superhelical twists, and how a very stable framework may be constructed for future functional designs.
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(as it appears on PubMed at http://www.pubmed.gov), where 12737816 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12737816}}
==About this Structure==
==About this Structure==
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[[Category: Design]]
[[Category: Design]]
[[Category: Tpr]]
[[Category: Tpr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:16:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:20:47 2008''

Revision as of 11:20, 28 July 2008

Image:1na0.png

Template:STRUCTURE 1na0

Design of Stable alpha-Helical Arrays from an Idealized TPR Motif

Template:ABSTRACT PUBMED 12737816

About this Structure

Full crystallographic information is available from OCA.

Reference

Design of stable alpha-helical arrays from an idealized TPR motif., Main ER, Xiong Y, Cocco MJ, D'Andrea L, Regan L, Structure. 2003 May;11(5):497-508. PMID:12737816

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