1zgl

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[[Image:1zgl.gif|left|200px]]
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{{STRUCTURE_1zgl| PDB=1zgl | SCENE= }}
{{STRUCTURE_1zgl| PDB=1zgl | SCENE= }}
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'''Crystal structure of 3A6 TCR bound to MBP/HLA-DR2a'''
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===Crystal structure of 3A6 TCR bound to MBP/HLA-DR2a===
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==Overview==
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Multiple sclerosis is mediated by T-cell responses to central nervous system antigens such as myelin basic protein (MBP). To investigate self-peptide/major histocompatibility complex (MHC) recognition and T-cell receptor (TCR) degeneracy, we determined the crystal structure, at 2.8 A resolution, of an autoimmune TCR (3A6) bound to an MBP self-peptide and the multiple sclerosis-associated MHC class II molecule, human leukocyte antigen (HLA)-DR2a. The complex reveals that 3A6 primarily recognizes the N-terminal portion of MBP, in contrast with antimicrobial and alloreactive TCRs, which focus on the peptide center. Moreover, this binding mode, which may be frequent among autoimmune TCRs, is compatible with a wide range of orientation angles of TCR to peptide/MHC. The interface is characterized by a scarcity of hydrogen bonds between TCR and peptide, and TCR-induced conformational changes in MBP/HLA-DR2a, which likely explain the low observed affinity. Degeneracy of 3A6, manifested by recognition of superagonist peptides bearing substitutions at nearly all TCR-contacting positions, results from the few specific interactions between 3A6 and MBP, allowing optimization of interface complementarity through variations in the peptide.
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(as it appears on PubMed at http://www.pubmed.gov), where 16079912 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16079912}}
==About this Structure==
==About this Structure==
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[[Category: Quandt, J A.]]
[[Category: Quandt, J A.]]
[[Category: Tcr/peptide/mhc complex]]
[[Category: Tcr/peptide/mhc complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:35:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:24:24 2008''

Revision as of 11:24, 28 July 2008

Image:1zgl.png

Template:STRUCTURE 1zgl

Crystal structure of 3A6 TCR bound to MBP/HLA-DR2a

Template:ABSTRACT PUBMED 16079912

About this Structure

1ZGL is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule., Li Y, Huang Y, Lue J, Quandt JA, Martin R, Mariuzza RA, EMBO J. 2005 Sep 7;24(17):2968-79. Epub 2005 Aug 4. PMID:16079912

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