1vig

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1vig.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1vig.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1vig| PDB=1vig | SCENE= }}
{{STRUCTURE_1vig| PDB=1vig | SCENE= }}
-
'''NMR STUDY OF VIGILIN, REPEAT 6, 40 STRUCTURES'''
+
===NMR STUDY OF VIGILIN, REPEAT 6, 40 STRUCTURES===
-
==Overview==
+
<!--
-
The KH module is a sequence motif found in a number of proteins that are known to be in close association with RNA. Experimental evidence suggests a direct involvement of KH in RNA binding. The human FMR1 protein, which has two KH domains, is associated with fragile X syndrome, the most common inherited cause of mental retardation. Here we present the three-dimensional solution structure of the KH module. The domain consists of a stable beta alpha alpha beta beta alpha fold. On the basis of our results, we suggest a potential surface for RNA binding centered on the loop between the first two helices. Substitution of a well-conserved hydrophobic residue located on the second helix destroys the KH fold; a mutation of this position in FMR1 leads to an aggravated fragile X phenotype.
+
The line below this paragraph, {{ABSTRACT_PUBMED_8612276}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 8612276 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_8612276}}
==About this Structure==
==About this Structure==
-
1VIG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VIG OCA].
+
1VIG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VIG OCA].
==Reference==
==Reference==
Line 30: Line 34:
[[Category: Stier, G.]]
[[Category: Stier, G.]]
[[Category: Rna-binding protein]]
[[Category: Rna-binding protein]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:34:05 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:26:42 2008''

Revision as of 11:26, 28 July 2008

Image:1vig.png

Template:STRUCTURE 1vig

NMR STUDY OF VIGILIN, REPEAT 6, 40 STRUCTURES

Template:ABSTRACT PUBMED 8612276

About this Structure

1VIG is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Three-dimensional structure and stability of the KH domain: molecular insights into the fragile X syndrome., Musco G, Stier G, Joseph C, Castiglione Morelli MA, Nilges M, Gibson TJ, Pastore A, Cell. 1996 Apr 19;85(2):237-45. PMID:8612276

Page seeded by OCA on Mon Jul 28 14:26:42 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1vig"
Personal tools