2bx5

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{{STRUCTURE_2bx5| PDB=2bx5 | SCENE= }}
{{STRUCTURE_2bx5| PDB=2bx5 | SCENE= }}
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'''IS FR1 THE ANTIBODY'S ACHILLIES HEEL'''
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===IS FR1 THE ANTIBODY'S ACHILLIES HEEL===
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==Overview==
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Antibodies are the archetypal molecules of the Ig-fold superfamily. Their highly conserved beta-sheet architecture has evolved to avoid aggregation by protecting edge strands. However, the crystal structure of a human V kappa domain described here, reveals an exposed beta-edge strand which mediates assembly of a helical pentadecameric oligomer. This edge strand is highly conserved in V kappa domains but is both shortened and capped by the use of two sequential trans-proline residues in V lambda domains. We suggest that the exposure of this beta-edge in V kappa domains may explain why light-chain deposition disease is mediated predominantly by kappa antibodies.
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(as it appears on PubMed at http://www.pubmed.gov), where 17292396 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17292396}}
==About this Structure==
==About this Structure==
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[[Category: Lcdd]]
[[Category: Lcdd]]
[[Category: Light-chain]]
[[Category: Light-chain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:55:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:26:58 2008''

Revision as of 11:27, 28 July 2008

Image:2bx5.png

Template:STRUCTURE 2bx5

IS FR1 THE ANTIBODY'S ACHILLIES HEEL

Template:ABSTRACT PUBMED 17292396

About this Structure

2BX5 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Beta-edge interactions in a pentadecameric human antibody V kappa domain., James LC, Jones PC, McCoy A, Tennent GA, Pepys MB, Famm K, Winter G, J Mol Biol. 2007 Mar 30;367(3):603-8. Epub 2006 Nov 3. PMID:17292396

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