This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2bx5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2bx5.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2bx5.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2bx5| PDB=2bx5 | SCENE= }}
{{STRUCTURE_2bx5| PDB=2bx5 | SCENE= }}
-
'''IS FR1 THE ANTIBODY'S ACHILLIES HEEL'''
+
===IS FR1 THE ANTIBODY'S ACHILLIES HEEL===
-
==Overview==
+
<!--
-
Antibodies are the archetypal molecules of the Ig-fold superfamily. Their highly conserved beta-sheet architecture has evolved to avoid aggregation by protecting edge strands. However, the crystal structure of a human V kappa domain described here, reveals an exposed beta-edge strand which mediates assembly of a helical pentadecameric oligomer. This edge strand is highly conserved in V kappa domains but is both shortened and capped by the use of two sequential trans-proline residues in V lambda domains. We suggest that the exposure of this beta-edge in V kappa domains may explain why light-chain deposition disease is mediated predominantly by kappa antibodies.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17292396}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17292396 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17292396}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Lcdd]]
[[Category: Lcdd]]
[[Category: Light-chain]]
[[Category: Light-chain]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:55:19 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:26:58 2008''

Revision as of 11:27, 28 July 2008

Image:2bx5.png

Template:STRUCTURE 2bx5

IS FR1 THE ANTIBODY'S ACHILLIES HEEL

Template:ABSTRACT PUBMED 17292396

About this Structure

2BX5 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Beta-edge interactions in a pentadecameric human antibody V kappa domain., James LC, Jones PC, McCoy A, Tennent GA, Pepys MB, Famm K, Winter G, J Mol Biol. 2007 Mar 30;367(3):603-8. Epub 2006 Nov 3. PMID:17292396

Page seeded by OCA on Mon Jul 28 14:26:58 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2bx5"
Personal tools