2gtl

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[[Image:2gtl.gif|left|200px]]
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{{STRUCTURE_2gtl| PDB=2gtl | SCENE= }}
{{STRUCTURE_2gtl| PDB=2gtl | SCENE= }}
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'''Lumbricus Erythrocruorin at 3.5A resolution'''
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===Lumbricus Erythrocruorin at 3.5A resolution===
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==Overview==
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Annelid erythrocruorins are highly cooperative extracellular respiratory proteins with molecular masses on the order of 3.6 million Daltons. We report here the 3.5 A crystal structure of erythrocruorin from the earthworm Lumbricus terrestris. This structure reveals details of symmetrical and quasi-symmetrical interactions that dictate the self-limited assembly of 144 hemoglobin and 36 linker subunits. The linker subunits assemble into a core complex with D(6) symmetry onto which 12 hemoglobin dodecamers bind to form the entire complex. Although the three unique linker subunits share structural similarity, their interactions with each other and the hemoglobin subunits display striking diversity. The observed diversity includes design features that have been incorporated into the linker subunits and may be critical for efficient assembly of large quantities of this complex respiratory protein.
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(as it appears on PubMed at http://www.pubmed.gov), where 16843898 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16843898}}
==About this Structure==
==About this Structure==
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[[Category: Respiratory protein]]
[[Category: Respiratory protein]]
[[Category: Triple stranded helical coil]]
[[Category: Triple stranded helical coil]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:31:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:27:17 2008''

Revision as of 11:27, 28 July 2008

Image:2gtl.png

Template:STRUCTURE 2gtl

Lumbricus Erythrocruorin at 3.5A resolution

Template:ABSTRACT PUBMED 16843898

About this Structure

2GTL is a Protein complex structure of sequences from Lumbricus terrestris. Full crystallographic information is available from OCA.

Reference

Lumbricus erythrocruorin at 3.5 A resolution: architecture of a megadalton respiratory complex., Royer WE Jr, Sharma H, Strand K, Knapp JE, Bhyravbhatla B, Structure. 2006 Jul;14(7):1167-77. PMID:16843898

Page seeded by OCA on Mon Jul 28 14:27:17 2008

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