1otr

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[[Image:1otr.gif|left|200px]]
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{{Seed}}
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[[Image:1otr.png|left|200px]]
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{{STRUCTURE_1otr| PDB=1otr | SCENE= }}
{{STRUCTURE_1otr| PDB=1otr | SCENE= }}
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'''Solution Structure of a CUE-Ubiquitin Complex'''
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===Solution Structure of a CUE-Ubiquitin Complex===
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==Overview==
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Monoubiquitination serves as a regulatory signal in a variety of cellular processes. Monoubiquitin signals are transmitted by binding to a small but rapidly expanding class of ubiquitin binding motifs. Several of these motifs, including the CUE domain, also promote intramolecular monoubiquitination. The solution structure of a CUE domain of the yeast Cue2 protein in complex with ubiquitin reveals intermolecular interactions involving conserved hydrophobic surfaces, including the Leu8-Ile44-Val70 patch on ubiquitin. The contact surface extends beyond this patch and encompasses Lys48, a site of polyubiquitin chain formation. This suggests an occlusion mechanism for inhibiting polyubiquitin chain formation during monoubiquitin signaling. The CUE domain shares a similar overall architecture with the UBA domain, which also contains a conserved hydrophobic patch. Comparative modeling suggests that the UBA domain interacts analogously with ubiquitin. The structure of the CUE-ubiquitin complex may thus serve as a paradigm for ubiquitin recognition and signaling by ubiquitin binding proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 12787503 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12787503}}
==About this Structure==
==About this Structure==
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1OTR is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OTR OCA].
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1OTR is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OTR OCA].
==Reference==
==Reference==
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[[Category: Salerno, W J.]]
[[Category: Salerno, W J.]]
[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:16:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:30:15 2008''

Revision as of 11:30, 28 July 2008

Image:1otr.png

Template:STRUCTURE 1otr

Solution Structure of a CUE-Ubiquitin Complex

Template:ABSTRACT PUBMED 12787503

About this Structure

1OTR is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full experimental information is available from OCA.

Reference

Solution structure of a CUE-ubiquitin complex reveals a conserved mode of ubiquitin binding., Kang RS, Daniels CM, Francis SA, Shih SC, Salerno WJ, Hicke L, Radhakrishnan I, Cell. 2003 May 30;113(5):621-30. PMID:12787503

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