1ri7

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{{STRUCTURE_1ri7| PDB=1ri7 | SCENE= }}
{{STRUCTURE_1ri7| PDB=1ri7 | SCENE= }}
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'''crystal structure of a protein in the LRP/ASNC family from the hyperthermophilic archaeon Pyrococcus sp. OT3'''
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===crystal structure of a protein in the LRP/ASNC family from the hyperthermophilic archaeon Pyrococcus sp. OT3===
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==Overview==
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The classification feast/famine regulatory proteins (FFRPs) encompasses archaeal DNA-binding proteins with Escherichia coli transcription factors, the leucine-responsive regulatory protein and the asparagine synthase C gene product. In this paper, we describe two forms of the archaeal FFRP FL11 (pot0434017), both assembled from dimers. When crystallized, a helical cylinder is formed with six dimers per turn. In contrast, in solution, disks are formed, most likely consisting of four dimers each; an observation by cryoelectron microscopy. Whereas each dimer binds a 13-bp sequence, different forms will discriminate between promoters, based on the numbers of repeating 13-bp sequences, and types of linkers inserted between them, which are either of 7-8 or approximately 18 bp. The amino acid sequences of these FFRPs are designed to form the same type of 3D structures, and the transition between their assembly forms is regulated by interaction with small molecules. These considerations lead us to propose a possible mechanism for regulating a number of genes by varying assembly forms and by combining different FFRPs into these assemblies, responding to environmental changes.
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(as it appears on PubMed at http://www.pubmed.gov), where 14976242 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14976242}}
==About this Structure==
==About this Structure==
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[[Category: Lrp/asnc family]]
[[Category: Lrp/asnc family]]
[[Category: Transcription]]
[[Category: Transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:31:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:31:23 2008''

Revision as of 11:31, 28 July 2008

Image:1ri7.png

Template:STRUCTURE 1ri7

crystal structure of a protein in the LRP/ASNC family from the hyperthermophilic archaeon Pyrococcus sp. OT3

Template:ABSTRACT PUBMED 14976242

About this Structure

1RI7 is a Single protein structure of sequence from Pyrococcus sp.. Full crystallographic information is available from OCA.

Reference

The archaeal feast/famine regulatory protein: potential roles of its assembly forms for regulating transcription., Koike H, Ishijima SA, Clowney L, Suzuki M, Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2840-5. Epub 2004 Feb 19. PMID:14976242

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