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1u9v

From Proteopedia

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[[Image:1u9v.gif|left|200px]]
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{{Seed}}
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[[Image:1u9v.png|left|200px]]
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{{STRUCTURE_1u9v| PDB=1u9v | SCENE= }}
{{STRUCTURE_1u9v| PDB=1u9v | SCENE= }}
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'''Crystal Structure of the Cysteine Protease Human Cathepsin K in Complex with the Covalent Inhibitor NVP-ABE854'''
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===Crystal Structure of the Cysteine Protease Human Cathepsin K in Complex with the Covalent Inhibitor NVP-ABE854===
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==Overview==
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Starting from the high-throughput screening hit 1a, novel cathepsin K inhibitors have been developed based on a purine scaffold. High-resolution X-ray structures of several derivatives have revealed the binding mode of these unique cysteine protease inhibitors.
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The line below this paragraph, {{ABSTRACT_PUBMED_15537340}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15537340 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15537340}}
==About this Structure==
==About this Structure==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Sulfhydryl proteinase]]
[[Category: Sulfhydryl proteinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:56:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:34:43 2008''

Revision as of 11:34, 28 July 2008

Template:STRUCTURE 1u9v

Crystal Structure of the Cysteine Protease Human Cathepsin K in Complex with the Covalent Inhibitor NVP-ABE854

Template:ABSTRACT PUBMED 15537340

About this Structure

1U9V is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K., Altmann E, Cowan-Jacob SW, Missbach M, J Med Chem. 2004 Nov 18;47(24):5833-6. PMID:15537340

Page seeded by OCA on Mon Jul 28 14:34:43 2008

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