1vlk

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{{STRUCTURE_1vlk| PDB=1vlk | SCENE= }}
{{STRUCTURE_1vlk| PDB=1vlk | SCENE= }}
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'''STRUCTURE OF VIRAL INTERLEUKIN-10'''
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===STRUCTURE OF VIRAL INTERLEUKIN-10===
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==Overview==
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The crystal structure of Epstein-Barr virus protein BCRF1, an analog of cellular interleukin-10 (IL-10), has been determined at the resolution of 1.9 A and refined to an R-factor 0.191. The structure of this cytokine is similar to that of human IL-10 (hIL-10), forming an intercalated dimer of two 17 kDa polypeptides related by a crystallographic 2-fold symmetry axis. BCRF1 exhibits novel conformations of the N-terminal coil and of the loop between helices A and B compared to hIL-10. These regions are likely to be involved in binding of one or more components of the IL-10 receptor system, and thus the structural differences may account for the lower binding affinity and limited spectrum of biological activities of viral IL-10, compared to hIL-10.
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(as it appears on PubMed at http://www.pubmed.gov), where 9159483 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9159483}}
==About this Structure==
==About this Structure==
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[[Category: Glycoprotein]]
[[Category: Glycoprotein]]
[[Category: Signal]]
[[Category: Signal]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:35:22 2008''

Revision as of 11:35, 28 July 2008

Image:1vlk.png

Template:STRUCTURE 1vlk

STRUCTURE OF VIRAL INTERLEUKIN-10

Template:ABSTRACT PUBMED 9159483

About this Structure

1VLK is a Single protein structure of sequence from Human herpesvirus 4. Full crystallographic information is available from OCA.

Reference

Crystal structure of Epstein-Barr virus protein BCRF1, a homolog of cellular interleukin-10., Zdanov A, Schalk-Hihi C, Menon S, Moore KW, Wlodawer A, J Mol Biol. 1997 May 2;268(2):460-7. PMID:9159483

Page seeded by OCA on Mon Jul 28 14:35:22 2008

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