2c3s

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{{STRUCTURE_2c3s| PDB=2c3s | SCENE= }}
{{STRUCTURE_2c3s| PDB=2c3s | SCENE= }}
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'''STRUCTURE OF SARS COV MAIN PROTEINASE AT 1.9 A (PH6.5)'''
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===STRUCTURE OF SARS COV MAIN PROTEINASE AT 1.9 A (PH6.5)===
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==Overview==
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The 34 kDa main proteinase (Mpro) from the severe acute respiratory syndrome coronavirus (SARS-CoV) plays an important role in the virus life cycle through the specific processing of viral polyproteins. As such, SARS-CoV Mpro is a key target for the identification of specific inhibitors directed against the SARS virus. With a view to facilitating the development of such compounds, crystals were obtained of the enzyme at pH 6.5 in the orthorhombic space group P2(1)2(1)2 that diffract to a resolution of 1.9 A. These crystals contain one monomer per asymmetric unit and the biologically active dimer is generated via the crystallographic twofold axis. The conformation of the catalytic site indicates that the enzyme is active in the crystalline form and thus suitable for structure-based inhibition studies.
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{{ABSTRACT_PUBMED_16511208}}
==About this Structure==
==About this Structure==
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[[Category: Xu, T.]]
[[Category: Xu, T.]]
[[Category: Sars cov,3c-like protease,main protease,hydrolase]]
[[Category: Sars cov,3c-like protease,main protease,hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:12:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:38:58 2008''

Revision as of 11:39, 28 July 2008

Image:2c3s.png

Template:STRUCTURE 2c3s

STRUCTURE OF SARS COV MAIN PROTEINASE AT 1.9 A (PH6.5)

Template:ABSTRACT PUBMED 16511208

About this Structure

2C3S is a Single protein structure of sequence from Human sars coronavirus. This structure supersedes the now removed PDB entry 2bw6. Full crystallographic information is available from OCA.

Reference

Structure of the SARS coronavirus main proteinase as an active C2 crystallographic dimer., Xu T, Ooi A, Lee HC, Wilmouth R, Liu DX, Lescar J, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Nov 1;61(Pt, 11):964-6. Epub 2005 Oct 20. PMID:16511208

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